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GHK-Cu Topical (GHK-Cu Copper Peptide (Topical/Scalp))

Category: Hair Growth. Status: Cosmetic / Research compound.

The copper-peptide complex applied topically to the scalp to stimulate hair follicle regeneration. GHK-Cu increases follicle size, promotes angiogenesis around follicles, and extends the anagen growth phase through multiple growth factor pathways.

How it works

Activates genes for hair growth including VEGF, FGF, and nerve growth factor at the follicular level. Stimulates dermal papilla cell proliferation. Extends anagen phase via Wnt/β-catenin pathway activation. Delivers copper for lysyl oxidase (collagen cross-linking).

Key facts

  • Molecular weight: 403.92 Da (with Cu)
  • Half-life: ~2-4 hours (topical depot at scalp)
  • Bioavailability: Topical penetration to dermal papilla
  • Storage: Refrigerate serum (2-8°C). Protect from light.

Dosing overview

  • Typical dose: 1-2 mg/mL in scalp solution or serum
  • Frequency: Daily application
  • Duration: 3-6 months minimum
  • Route: Topical scalp serum or mesotherapy injection

Reported benefits

  • Follicle stem cell activation
  • Increased hair follicle size
  • Scalp angiogenesis
  • Collagen remodeling in scalp
  • Compatible with all other treatments
  • Anti-inflammatory for scalp

Possible side effects

  • Mild scalp tingling
  • Blue/green staining (high concentrations)
  • Contact sensitivity (rare)
  • Generally very well-tolerated

Research

  • GHK-Cu and hair follicle regeneration (2020): GHK-Cu increased hair follicle size by 30%, extended anagen duration by 20%, and upregulated VEGF 3-fold in follicular tissue cultures.
  • Copper peptide scalp treatment (2021): Topical GHK-Cu serum improved hair density by 18% and hair thickness by 12% over 16 weeks in a pilot study of AGA patients.

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Research and educational reference only. Not medical advice.