HCG (Fertility) vs HMG
A side-by-side research comparison of HCG (Fertility) and HMG across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | HCG (Fertility) | HMG |
|---|---|---|
| Full name | HCG for Ovulation Trigger (Pregnyl/Ovidrel) | Human Menopausal Gonadotropin (Menotropins) |
| Category | Fertility | Fertility |
| Status | FDA Approved | FDA Approved |
| Mechanism | Binds LH/CG receptors on the dominant follicle, triggering resumption of meiosis in the oocyte, luteinization of granulosa cells, and follicular rupture (ovulation) within 36-40 hours of administration. | FSH component directly stimulates Sertoli cells to support spermatogenesis in men, and granulosa cells for follicle growth in women. LH component stimulates Leydig cells (testosterone) in men and theca cells (androgen precursors) in women. |
| Molecular weight | ~36,700 Da | FSH: ~35,000 Da; LH: ~30,000 Da |
| Half-life | ~33 hours | FSH: ~37 hours; LH: ~20 hours |
| Bioavailability | ~100% (subcutaneous/intramuscular) | ~100% (intramuscular/subcutaneous) |
| Typical dose | 5000-10,000 IU (Pregnyl) or 250 mcg (Ovidrel) | 75-150 IU |
| Frequency | Single injection timed to follicle maturity | 3x weekly (men) or daily (women, stimulation) |
| Route | Subcutaneous or intramuscular | Intramuscular or subcutaneous injection |
HCG (Fertility) reported benefits
- Precise ovulation timing
- Final oocyte maturation
- Corpus luteum support
- IUI/IVF timing coordination
- Luteal phase support
HMG reported benefits
- Spermatogenesis restoration
- Ovarian follicle stimulation
- Fertility recovery after TRT
- Improved sperm count and motility
- IVF protocol support
Related comparisons
Research and educational reference only. Not medical advice.