HMG (Human Menopausal Gonadotropin (Menotropins))
A purified preparation of FSH and LH extracted from postmenopausal urine. Used in fertility medicine to stimulate spermatogenesis in men and ovarian follicle development in women. Essential for TRT-induced azoospermia recovery.
How it works
FSH component directly stimulates Sertoli cells to support spermatogenesis in men, and granulosa cells for follicle growth in women. LH component stimulates Leydig cells (testosterone) in men and theca cells (androgen precursors) in women.
Key facts
- Molecular weight: FSH: ~35,000 Da; LH: ~30,000 Da
- Half-life: FSH: ~37 hours; LH: ~20 hours
- Bioavailability: ~100% (intramuscular/subcutaneous)
- Storage: Refrigerate (2-8°C). Reconstituted: use within 28 days.
Dosing overview
- Typical dose: 75-150 IU
- Frequency: 3x weekly (men) or daily (women, stimulation)
- Duration: 3-6 months (men); 8-12 days (women IVF)
- Route: Intramuscular or subcutaneous injection
Reported benefits
- Spermatogenesis restoration
- Ovarian follicle stimulation
- Fertility recovery after TRT
- Improved sperm count and motility
- IVF protocol support
Possible side effects
- Injection site pain
- Ovarian hyperstimulation (women)
- Headache
- Mood swings
- Gynecomastia (men, rare)
- Multiple pregnancy risk (women)
Research
- HMG for TRT-induced azoospermia (2021): HMG + HCG combination restored spermatogenesis in 85% of previously azoospermic TRT patients within 6-12 months.
- Gonadotropins and male fertility (2022): FSH/LH therapy improved sperm concentration from 0 to >5 million/mL in 70% of men with hypogonadotropic hypogonadism.
Compare HMG
Community discussions about HMG
- Bergamot Extract as a Natural Statin Alternative – My Thought After Reading the Latest Study - 13 comments
- HMG + HCG mono therapy restart, does timing matter more than dose for guys coming off TRT? - 4 comments
- Ask the community about HMG
Research and educational reference only. Not medical advice.