ResearchSafe

HMG (Human Menopausal Gonadotropin (Menotropins))

Category: Fertility. Status: FDA Approved.

A purified preparation of FSH and LH extracted from postmenopausal urine. Used in fertility medicine to stimulate spermatogenesis in men and ovarian follicle development in women. Essential for TRT-induced azoospermia recovery.

How it works

FSH component directly stimulates Sertoli cells to support spermatogenesis in men, and granulosa cells for follicle growth in women. LH component stimulates Leydig cells (testosterone) in men and theca cells (androgen precursors) in women.

Key facts

  • Molecular weight: FSH: ~35,000 Da; LH: ~30,000 Da
  • Half-life: FSH: ~37 hours; LH: ~20 hours
  • Bioavailability: ~100% (intramuscular/subcutaneous)
  • Storage: Refrigerate (2-8°C). Reconstituted: use within 28 days.

Dosing overview

  • Typical dose: 75-150 IU
  • Frequency: 3x weekly (men) or daily (women, stimulation)
  • Duration: 3-6 months (men); 8-12 days (women IVF)
  • Route: Intramuscular or subcutaneous injection

Reported benefits

  • Spermatogenesis restoration
  • Ovarian follicle stimulation
  • Fertility recovery after TRT
  • Improved sperm count and motility
  • IVF protocol support

Possible side effects

  • Injection site pain
  • Ovarian hyperstimulation (women)
  • Headache
  • Mood swings
  • Gynecomastia (men, rare)
  • Multiple pregnancy risk (women)

Research

  • HMG for TRT-induced azoospermia (2021): HMG + HCG combination restored spermatogenesis in 85% of previously azoospermic TRT patients within 6-12 months.
  • Gonadotropins and male fertility (2022): FSH/LH therapy improved sperm concentration from 0 to >5 million/mL in 70% of men with hypogonadotropic hypogonadism.

Community reviews of HMG

Rated 4.5 out of 5 from 6 community reviews by ResearchSafe members.

  • needle_notes_nate rated it 5/5 - Genuinely effective after 3 months: Been using HMG for about 3 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
  • cycling_chad rated it 4/5 - Worth adding to the protocol: HMG has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
  • bio_optimal rated it 4/5 - Noticed clear benefits within weeks: Added HMG to my protocol about 6 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
  • theo_benchpr rated it 4/5 - HMG helped move the needle, with one annoying tradeoff: I ran HMG for about 12 weeks while I was trying to get my fertility back in shape after TRT, and for me it seemed to do something real. I’m a software engineer on the East Coast, so I spend way too much time sitting, staring at a screen, and second guessing lab work. My bottom line is simple, I felt better about the direction I was headed, and my follow-up numbers looked more encouraging than before. The one caveat was the injections got old fast, and I had a couple days where I felt a little off after them. Still, for my own experience, I’d call it a solid 4 out of 5.
  • halflife_harry rated it 5/5 - Solid compound with real results: Been using HMG for about 2 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
  • greg_labrat rated it 5/5 - HMG brought my sperm counts back into play: For me, the biggest change was semen volume and, later, the feeling that fertility was actually moving again after TRT, which was the whole point. I ran HMG about 4 weeks while living in the Netherlands and working long hours as a software engineer, and tbh I was pleasantly surprised.

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Community discussions about HMG

Research and educational reference only. Not medical advice.