Ibogaine vs Muscimol
A side-by-side research comparison of Ibogaine and Muscimol across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ibogaine | Muscimol |
|---|---|---|
| Full name | Ibogaine (from Tabernanthe iboga) | Muscimol (Amanita muscaria) |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Natural compound; legal in many regions |
| Mechanism | Acts on multiple systems at once, including serotonin and opioid receptors, NMDA receptors and nicotinic receptors. Its active metabolite noribogaine is thought to drive much of the lasting anti-addiction effect. | Activates GABA-A receptors (the brain's main calming system), producing sedation, dreaminess and altered perception rather than classic visuals. |
| Molecular weight | 310.43 g/mol | 114.10 g/mol |
| Half-life | ~4-7 hours (ibogaine); noribogaine much longer | Several hours |
| Bioavailability | Oral | Oral |
| Typical dose | Weight-based, given in specialized clinics | Varies by individual and setting |
| Frequency | Usually a single session | Occasional |
| Route | Oral, under medical and cardiac monitoring | Oral |
Ibogaine reported benefits
- Studied for opioid use disorder
- Can reduce withdrawal symptoms quickly
- May lower cravings after a single session
- Investigated for traumatic brain injury (with magnesium) in veterans
Muscimol reported benefits
- Different (GABA) mechanism
- Sedating, dreamlike effects
- Long traditional use
- Legal in many places
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Research and educational reference only. Not medical advice.