Ibogaine vs Salvinorin A
A side-by-side research comparison of Ibogaine and Salvinorin A across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ibogaine | Salvinorin A |
|---|---|---|
| Full name | Ibogaine (from Tabernanthe iboga) | Salvinorin A (Salvia divinorum) |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Varies by region; research compound |
| Mechanism | Acts on multiple systems at once, including serotonin and opioid receptors, NMDA receptors and nicotinic receptors. Its active metabolite noribogaine is thought to drive much of the lasting anti-addiction effect. | Activates kappa-opioid receptors (not serotonin receptors), which makes its effects unlike LSD or psilocybin. |
| Molecular weight | 310.43 g/mol | 432.46 g/mol |
| Half-life | ~4-7 hours (ibogaine); noribogaine much longer | Very short |
| Bioavailability | Oral | Oral |
| Typical dose | Weight-based, given in specialized clinics | Varies by individual and setting |
| Frequency | Usually a single session | Occasional |
| Route | Oral, under medical and cardiac monitoring | Smoked, vaporized or held in the mouth |
Ibogaine reported benefits
- Studied for opioid use disorder
- Can reduce withdrawal symptoms quickly
- May lower cravings after a single session
- Investigated for traumatic brain injury (with magnesium) in veterans
Salvinorin A reported benefits
- Unique kappa-opioid mechanism
- Very short experience
- Long traditional Mazatec use
- Of interest for depression research
Related comparisons
Research and educational reference only. Not medical advice.