LGD-4033 vs MGF (Mechano Growth Factor)
A side-by-side research comparison of LGD-4033 and MGF (Mechano Growth Factor) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | LGD-4033 | MGF (Mechano Growth Factor) |
|---|---|---|
| Full name | Ligandrol (LGD-4033) | Mechano Growth Factor (IGF-1Ec splice variant) |
| Category | Muscle Growth | Muscle Growth |
| Status | Investigational | Research compound |
| Mechanism | Selectively binds androgen receptors in muscle and bone, activating anabolic gene transcription while avoiding prostate activity. | Unique E-domain activates quiescent satellite cells for proliferation. Distinct from IGF-1Ea which drives differentiation. PEGylated form extends short half-life. |
| Molecular weight | 338.25 Da | 2,867 Da (synthetic fragment) |
| Half-life | ~24-36 hours | 5-7 min (native) / 24-48h (PEGylated) |
| Bioavailability | ~90% oral | High (local IM) |
| Typical dose | 5-10 mg | 100-200 mcg PEG-MGF |
| Frequency | Once daily | 2-3x per week |
| Route | Oral | Intramuscular (local) |
LGD-4033 reported benefits
- Significant lean mass gains
- Bone density improvement
- Oral convenience
- Selective tissue activity
MGF (Mechano Growth Factor) reported benefits
- Satellite cell activation
- Muscle-specific growth
- Repair response enhancement
- Synergistic with training
- Local hypertrophy
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Research and educational reference only. Not medical advice.