MGF (Mechano Growth Factor) (Mechano Growth Factor (IGF-1Ec splice variant))
An IGF-1 splice variant produced locally in muscle from mechanical stimulation. Activates satellite stem cells initiating repair and growth response to training.
How it works
Unique E-domain activates quiescent satellite cells for proliferation. Distinct from IGF-1Ea which drives differentiation. PEGylated form extends short half-life.
Key facts
- Molecular weight: 2,867 Da (synthetic fragment)
- Half-life: 5-7 min (native) / 24-48h (PEGylated)
- Bioavailability: High (local IM)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 7 days.
Dosing overview
- Typical dose: 100-200 mcg PEG-MGF
- Frequency: 2-3x per week
- Duration: 4-6 weeks
- Route: Intramuscular (local)
Reported benefits
- Satellite cell activation
- Muscle-specific growth
- Repair response enhancement
- Synergistic with training
- Local hypertrophy
Possible side effects
- Injection site soreness
- Rapid degradation (non-PEG)
- Limited human data
Research
- MGF expression in human muscle post-exercise (2020): MGF mRNA increased 400% within 4 hours post-training, preceding satellite cell activation.
- PEGylated MGF for muscle regeneration (2021): Increased satellite cells by 250% and accelerated functional recovery by 40%.
Compare MGF (Mechano Growth Factor)
Research and educational reference only. Not medical advice.