Mesterolone vs Nandrolone Decanoate
A side-by-side research comparison of Mesterolone and Nandrolone Decanoate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Mesterolone | Nandrolone Decanoate |
|---|---|---|
| Full name | Mesterolone (Proviron) | Nandrolone Decanoate (Deca-Durabolin) |
| Category | Anabolic Steroids | Anabolic Steroids |
| Status | Prescription drug (controlled substance) | Prescription drug (controlled substance) |
| Mechanism | Mesterolone is a DHT derivative that is orally active without 17aa alkylation (so low liver stress). It binds SHBG strongly, freeing up other androgens, and has anti-estrogenic effects, but weak muscle-building activity on its own. | Nandrolone is testosterone lacking the 19-carbon methyl group, giving it high anabolic and lower androgenic activity. It binds androgen receptors and, unlike testosterone, converts to a weaker androgen (rather than DHT) in some tissues, reducing certain androgenic effects but not estrogen-related ones. |
| Molecular weight | 304.5 Da | 428.6 Da |
| Half-life | ~12 hours | ~6-12 days |
| Bioavailability | Oral | Intramuscular injection |
| Typical dose | Medical: ~25-75 mg/day | Medical: ~50-100 mg every 1-4 weeks |
| Frequency | Daily (1-3 doses) | Weekly to monthly (medical) |
| Route | Oral tablet | Intramuscular injection |
Mesterolone reported benefits
- Lowers SHBG (more free androgen)
- Anti-estrogenic effect
- Muscle hardness
- Low liver stress
- Supports libido
Nandrolone Decanoate reported benefits
- Lean muscle mass gains
- Reputed joint comfort
- Increased red blood cell production
- Treats certain anemias/wasting (medical)
- Improved nitrogen retention
Related comparisons
Research and educational reference only. Not medical advice.