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Mesterolone (Mesterolone (Proviron))

Category: Anabolic Steroids. Status: Prescription drug (controlled substance).

An oral DHT-derived androgen (Proviron) used medically for androgen deficiency and, non-medically, more as an ancillary to lower SHBG and add "hardness" than as a mass-builder. Educational reference only.

How it works

Mesterolone is a DHT derivative that is orally active without 17aa alkylation (so low liver stress). It binds SHBG strongly, freeing up other androgens, and has anti-estrogenic effects, but weak muscle-building activity on its own.

Key facts

  • Molecular weight: 304.5 Da
  • Half-life: ~12 hours
  • Bioavailability: Oral
  • Storage: Room temperature; keep dry.

Dosing overview

  • Typical dose: Medical: ~25-75 mg/day
  • Frequency: Daily (1-3 doses)
  • Duration: Ongoing (medical) or ancillary
  • Route: Oral tablet

Protocol notes

  • Medically used for androgen deficiency and some fertility contexts.
  • Non-medically used as an ancillary to lower SHBG and reduce estrogenic effects.
  • Not a primary mass-builder.

Reported benefits

  • Lowers SHBG (more free androgen)
  • Anti-estrogenic effect
  • Muscle hardness
  • Low liver stress
  • Supports libido

Possible side effects

  • Androgenic hair loss
  • Prostate effects
  • Testosterone suppression (high doses)
  • Limited anabolic effect alone

Research

  • Mesterolone and SHBG (2015): Reduced SHBG and exhibited anti-estrogenic activity, supporting its ancillary use.

Compare Mesterolone

Research and educational reference only. Not medical advice.