NAD+ vs Urolithin A
A side-by-side research comparison of NAD+ and Urolithin A across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | NAD+ | Urolithin A |
|---|---|---|
| Full name | Nicotinamide Adenine Dinucleotide (NAD+ / NMN / NR) | Urolithin A (Mitophagy Activator) |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Dietary compound (clinical studies) |
| Mechanism | NAD+ serves as cofactor for sirtuins (SIRT1-7), PARPs (DNA repair), and CD38. Declining NAD+ impairs mitochondrial function and epigenetic maintenance. Restoration reactivates longevity pathways. | Stimulates mitophagy - the selective recycling of damaged mitochondria - improving mitochondrial quality and energy efficiency in muscle and other tissues. |
| Molecular weight | 663.4 Da | 228.20 Da |
| Half-life | 1-4 hours (IV), 4-8h (oral precursors) | Several hours |
| Bioavailability | 100% (IV), variable (oral 5-30%) | Oral; bypasses the need for the gut bacteria many people lack |
| Typical dose | 250-500mg IV or 500-1000mg NMN oral | 500-1000 mg per day |
| Frequency | Weekly (IV) or Daily (oral) | Once daily |
| Route | IV infusion or Oral (precursors) | Oral |
NAD+ reported benefits
- Restored cellular energy
- Enhanced DNA repair
- Sirtuin activation
- Improved mitochondrial function
- Cognitive clarity
- Anti-aging
Urolithin A reported benefits
- Improves mitochondrial function (mitophagy)
- Increased muscle endurance
- Cellular energy support
- Studied for healthy aging
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Research and educational reference only. Not medical advice.