SS-31 (Elamipretide) vs Urolithin A
A side-by-side research comparison of SS-31 (Elamipretide) and Urolithin A across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | SS-31 (Elamipretide) | Urolithin A |
|---|---|---|
| Full name | SS-31 / Elamipretide (Bendavia) | Urolithin A (Mitophagy Activator) |
| Category | Anti-Aging | Anti-Aging |
| Status | Investigational | Dietary compound (clinical studies) |
| Mechanism | Targets cardiolipin in inner mitochondrial membrane, stabilizes cytochrome c binding, optimizes electron transfer efficiency, and reduces mitochondrial ROS by 50%. | Stimulates mitophagy - the selective recycling of damaged mitochondria - improving mitochondrial quality and energy efficiency in muscle and other tissues. |
| Molecular weight | 640.8 Da | 228.20 Da |
| Half-life | 4-6 hours | Several hours |
| Bioavailability | High (SubQ) | Oral; bypasses the need for the gut bacteria many people lack |
| Typical dose | 5-40 mg | 500-1000 mg per day |
| Frequency | Daily | Once daily |
| Route | Subcutaneous or IV | Oral |
SS-31 (Elamipretide) reported benefits
- Mitochondrial function optimization
- Reduced oxidative stress
- Cardioprotection
- Improved exercise capacity
- Renal protection
- Cellular energy
Urolithin A reported benefits
- Improves mitochondrial function (mitophagy)
- Increased muscle endurance
- Cellular energy support
- Studied for healthy aging
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Research and educational reference only. Not medical advice.