Adipotide (Adipotide (FTPP / Prohibitin-Targeting Peptide))
An experimental peptidomimetic designed to trigger targeted fat loss by cutting off the blood supply to white adipose tissue. It remains preclinical and is frequently searched by biohackers alongside other fat-loss peptides, but carries notable safety concerns.
How it works
A fusion of a prohibitin-targeting peptide and a pro-apoptotic sequence. It binds prohibitin on the vasculature that feeds white fat, inducing apoptosis of those blood vessels, which starves fat cells and causes them to be resorbed.
Key facts
- Molecular weight: ~2.6 kDa
- Half-life: Short (hours)
- Bioavailability: Subcutaneous injection
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C, use quickly.
Dosing overview
- Typical dose: Not established for human use
- Frequency: Research protocols only
- Duration: Short experimental courses
- Route: Subcutaneous injection
Protocol notes
- No validated human dosing exists; all human protocols are experimental and unapproved.
- Animal studies used weight-based dosing over short courses (weeks).
- Kidney monitoring was required in primate studies due to renal effects.
Reported benefits
- Rapid targeted white-fat reduction (animal models)
- Weight loss without appetite suppression
- Reversal of metabolic markers in obese primates
Possible side effects
- Kidney toxicity (dose-dependent)
- Dehydration
- Injection site reactions
- Unknown long-term human safety
- No approved human use
Research
- Adipotide induces weight loss in obese primates (2011): Produced significant fat loss and improved insulin resistance in obese rhesus monkeys, but with reversible kidney effects.
- Prohibitin-targeting vascular ablation of fat (2004): Demonstrated the proof of concept that ablating adipose vasculature causes rapid fat resorption in mice.
Community reviews of Adipotide
- peptide_sarah rated it 5/5 - Worth adding to the protocol: Adipotide has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- research_marcus rated it 5/5 - Genuinely effective after 6 months: Been using Adipotide for about 6 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- subq_samantha rated it 5/5 - Noticed clear benefits within weeks: Added Adipotide to my protocol about 3 weeks ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
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Community discussions about Adipotide
- Thoughts on the latest Adipotide fat‑loss peptide article I saw - 4 comments
- Ask the community about Adipotide
Research and educational reference only. Not medical advice.