Alprostadil (Alprostadil (Prostaglandin E1))
A synthetic form of prostaglandin E1 used to treat erectile dysfunction by directly relaxing penile blood vessels. It works independently of sexual arousal and is delivered by injection or urethral suppository under medical guidance.
How it works
Alprostadil activates prostaglandin receptors that raise intracellular cAMP in cavernosal smooth muscle, causing vasodilation and increased blood inflow to produce an erection regardless of nerve signaling or arousal.
Key facts
- Molecular weight: 354.5 Da
- Half-life: Very short (minutes, locally metabolized)
- Bioavailability: Intracavernosal injection or intraurethral suppository
- Storage: Refrigerate; follow product-specific instructions.
Dosing overview
- Typical dose: Provider-titrated per response
- Frequency: As needed before activity
- Duration: On demand
- Route: Intracavernosal injection or urethral pellet
Protocol notes
- Dose is individually titrated by a physician starting at a low amount to find the minimum effective dose.
- Administered shortly before intended activity; effect is rapid and local.
- A component of TriMix, but also used as a standalone agent.
Reported benefits
- Effective for erectile dysfunction
- Works independent of arousal
- Rapid onset
- Useful when oral PDE5 inhibitors fail
Possible side effects
- Penile pain
- Prolonged erection/priapism
- Injection site bruising
- Dizziness
- Rare fibrosis with repeated use
Research
- Alprostadil for erectile dysfunction (2018): Intracavernosal alprostadil produced reliable erections in a majority of men, including PDE5-inhibitor non-responders.
Community reviews of Alprostadil
- morning_protocol rated it 4/5 - Genuinely effective after 2 weeks: Been using Alprostadil for about 2 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- trough_tracker_tim rated it 4/5 - Noticed clear benefits within weeks: Added Alprostadil to my protocol about 4 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- morning_pin_maya rated it 4/5 - Worth adding to the protocol: Alprostadil has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
Compare Alprostadil
Community discussions about Alprostadil
- Thoughts on the latest alprostadil update in the peptide database - 4 comments
- Alprostadil Injection Bruising: How I Handled It and My Questions - 3 comments
- Ask the community about Alprostadil
Research and educational reference only. Not medical advice.