B12 Injection (Methylcobalamin (Vitamin B12) Injectable)
Methylcobalamin is the active, methylated form of vitamin B12. Injectable B12 is one of the most commonly prescribed telemedicine treatments for energy, cognitive function, and nerve health. Essential for over 100 enzymatic reactions.
How it works
Cofactor for methionine synthase (DNA methylation) and methylmalonyl-CoA mutase (energy metabolism). Supports myelin synthesis, neurotransmitter production, and red blood cell formation.
Key facts
- Molecular weight: 1344.38 Da
- Half-life: ~6 days
- Bioavailability: ~100% IM/SC
- Storage: Refrigerate 2-8°C. Protect from light.
Dosing overview
- Typical dose: 1000-5000 mcg
- Frequency: 1-3x per week
- Duration: Ongoing
- Route: Intramuscular or subcutaneous injection
Protocol notes
- Repletion phase: ~1000 mcg several times in the first week or two, then taper to maintenance.
- Maintenance: ~1000 mcg every 1-4 weeks, or higher (up to 5000 mcg) weekly for symptom control.
- Methylcobalamin is the active form preferred for nerve/cognitive goals over cyanocobalamin.
Reported benefits
- Increased energy
- Improved cognitive function
- Nerve repair
- Red blood cell production
- Better sleep
- Mood enhancement
Possible side effects
- Injection site soreness
- Mild diarrhea
- Itching
- Anxiety (rare)
- Headache
Research
- Methylcobalamin and cognitive function (2022): Regular B12 injections improved verbal memory and processing speed in patients with suboptimal levels.
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Research and educational reference only. Not medical advice.