ResearchSafe

CJC-1295 (CJC-1295 (Modified GRF 1-29))

Category: Growth Hormone. Status: Research compound.

A synthetic GHRH analog with 4 amino acid substitutions for stability. Often combined with DAC for extended half-life or used without DAC for pulsatile release.

How it works

Binds GHRH receptors on anterior pituitary somatotrophs, stimulating cAMP-dependent GH synthesis and pulsatile release.

Key facts

  • Molecular weight: 3,368 Da (without DAC)
  • Half-life: 30 minutes (no DAC) / 8 days (with DAC)
  • Bioavailability: High (SubQ)
  • Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 21 days.

Dosing overview

  • Typical dose: 100-300 mcg
  • Frequency: 1-3x daily (no-DAC)
  • Duration: 8-16 weeks
  • Route: Subcutaneous injection

Protocol notes

  • No-DAC (Mod GRF 1-29) is almost always paired with a GHRP (ipamorelin/GHRP-2) for a synergistic GH pulse.
  • Typical: 100 mcg CJC + 100-200 mcg ipamorelin, injected together.
  • Dose 1-3x daily: pre-bed is the highest-value pulse; pre-workout and fasted-morning are common adds.

Reported benefits

  • Increased GH production
  • Improved body composition
  • Enhanced recovery
  • Better sleep quality
  • Anti-aging effects
  • Fat loss

Possible side effects

  • Flushing
  • Headache
  • Water retention
  • Tingling/numbness
  • Increased hunger

Research

  • CJC-1295 effects on GH secretion in healthy adults (2020): Increased mean GH levels by 200-1000% and IGF-1 by 50-70% sustained over 6-14 days after single injection.
  • Pulsatile vs sustained GH release with GHRH analogs (2019): Non-DAC CJC-1295 preserved physiological GH pulsatility while achieving 2-10x baseline elevation.

Community reviews of CJC-1295

Rated 4.7 out of 5 from 14 community reviews by ResearchSafe members.

  • bio_optimal rated it 5/5 - Gradual but consistent results: About 2 months into my CJC-1295 protocol and the compound is doing what it is supposed to. Sleep is deeper, skin quality is better, fat around the midsection is slowly reducing, and my recovery from training is improved. The key insight I have learned is patience. This is not an overnight transformation. It is a slow, steady optimization that compounds over weeks and months. People who quit after 2 weeks are not giving it enough time. Only downsides: some mild joint stiffness early on (actually a sign it is working) and the fasted dosing schedule is sometimes inconvenient. Worth it for the o
  • fasted_frank rated it 5/5 - Sleep quality improvement was the first thing I noticed: Running CJC-1295 for 3 months now, primarily for recovery and body composition. The first benefit I noticed was dramatically better sleep, deeper and more restorative, within the first week. Body composition changes came slower but are real. Leaner midsection, slightly fuller muscles, and my recovery between training sessions is noticeably improved. Not dramatic bodybuilder gains, more like everything works a bit better. Side effects have been minimal. Some water retention in the first 2 weeks that settled down, and occasional numbness in my fingers in the morning that goes away within an ho
  • bio_optimal rated it 5/5 - Body comp changes subtle but real: About 1 month into my CJC-1295 protocol and the compound is doing what it is supposed to. Sleep is deeper, skin quality is better, fat around the midsection is slowly reducing, and my recovery from training is improved. The key insight I have learned is patience. This is not an overnight transformation. It is a slow, steady optimization that compounds over weeks and months. People who quit after 2 weeks are not giving it enough time. Only downsides: some mild joint stiffness early on (actually a sign it is working) and the fasted dosing schedule is sometimes inconvenient. Worth it for the ov
  • bac_water_betty rated it 4/5 - Better recovery and deeper sleep at 2 months: CJC-1295 has been a solid addition to my protocol. The GH release translates to better sleep, improved recovery, and a gradual improvement in body composition that I did not get from training alone. I track my sleep with a wearable and my deep sleep percentage went from 12% to about 18-20% within the first two weeks. That alone is worth it for recovery. The body comp changes are more subtle but visible in progress photos over 2-3 months. No significant side effects at the doses I am running. Occasionally wake up with slightly puffy hands but it resolves within an hour. Recommend starting con
  • researcher465 rated it 5/5 - Better recovery than I got from GHRP-2 alone: I ran CJC-1295 for about 6 weeks while I was in Japan training through a heavy block and long recovery runs. For me it seemed to make mornings smoother, and my legs felt less flat after hard sessions. I had tried GHRP-2 before for the same recovery goal, and I preferred CJC-1295 because it felt steadier and a little more clean. Could be partly placebo, but the change was clear to me.
  • sanjay_swims rated it 4/5 - steadier recovery over 3 months, with a small catch: i ran cjc-1295 for about 3 months while juggling software work in the uk and keeping my swim training moving. week 1, honestly, not much. by week 2 or 3 i started waking up a bit fresher, and my legs felt less cooked after hard sessions. month 2 was where it felt most noticeable, recovery between training blocks seemed smoother. by month 3 it was still helpful, though the sleep boost got a bit less obvious. i’d call it solid 4/5 for me.

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Research and educational reference only. Not medical advice.