CJC-1295 DAC (CJC-1295 with Drug Affinity Complex)
CJC-1295 conjugated with DAC that binds albumin, extending half-life to ~8 days. Creates sustained GH elevation rather than pulsatile release.
How it works
The DAC moiety binds serum albumin creating a depot that slowly releases active CJC-1295 for continuous GHRH signaling.
Key facts
- Molecular weight: 3,647 Da
- Half-life: 8 days
- Bioavailability: High (SubQ)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 21 days.
Dosing overview
- Typical dose: 2 mg
- Frequency: 1-2x per week
- Duration: 8-16 weeks
- Route: Subcutaneous
Reported benefits
- Once/twice weekly dosing
- Sustained IGF-1 elevation
- Convenient schedule
- Long-term body composition changes
Possible side effects
- Water retention
- Tingling/numbness
- Flushing
- Non-pulsatile GH pattern
- Fatigue
Research
- Pharmacokinetics of DAC-conjugated CJC-1295 (2019): Single 2mg dose elevated IGF-1 by 50-70% for 9-11 days via albumin-bound release.
- Sustained vs pulsatile GH elevation outcomes (2020): DAC version produced greater total GH exposure but less favorable body composition vs pulsatile non-DAC.
Compare CJC-1295 DAC
Community discussions about CJC-1295 DAC
- Feedback on adding CJC-1295 DAC to KLOW stack for ultra recovery – timing and safety? - 4 comments
- My 6‑week log with CJC-1295 DAC – what I noticed - 4 comments
- CJC-1295 DAC dosing – does twice weekly actually give steady GH spikes? - 5 comments
- Noticed water retention and tingling on CJC-1295 DAC – any tips to reduce it? - 6 comments
- Biohacking and anti-aging science – what’s real versus hype - 4 comments
- Ask the community about CJC-1295 DAC
Research and educational reference only. Not medical advice.