CJC-1295 DAC (CJC-1295 with Drug Affinity Complex)
CJC-1295 conjugated with DAC that binds albumin, extending half-life to ~8 days. Creates sustained GH elevation rather than pulsatile release.
How it works
The DAC moiety binds serum albumin creating a depot that slowly releases active CJC-1295 for continuous GHRH signaling.
Key facts
- Molecular weight: 3,647 Da
- Half-life: 8 days
- Bioavailability: High (SubQ)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 21 days.
Dosing overview
- Typical dose: 2 mg
- Frequency: 1-2x per week
- Duration: 8-16 weeks
- Route: Subcutaneous
Reported benefits
- Once/twice weekly dosing
- Sustained IGF-1 elevation
- Convenient schedule
- Long-term body composition changes
Possible side effects
- Water retention
- Tingling/numbness
- Flushing
- Non-pulsatile GH pattern
- Fatigue
Research
- Pharmacokinetics of DAC-conjugated CJC-1295 (2019): Single 2mg dose elevated IGF-1 by 50-70% for 9-11 days via albumin-bound release.
- Sustained vs pulsatile GH elevation outcomes (2020): DAC version produced greater total GH exposure but less favorable body composition vs pulsatile non-DAC.
Community reviews of CJC-1295 DAC
- loading_phase_lucy rated it 5/5 - Better recovery and deeper sleep at 3 months: CJC-1295 DAC has been a solid addition to my protocol. The GH release translates to better sleep, improved recovery, and a gradual improvement in body composition that I did not get from training alone. I track my sleep with a wearable and my deep sleep percentage went from 12% to about 18-20% within the first two weeks. That alone is worth it for recovery. The body comp changes are more subtle but visible in progress photos over 2-3 months. No significant side effects at the doses I am running. Occasionally wake up with slightly puffy hands but it resolves within an hour. Recommend starting
- protocol_pete rated it 5/5 - Body comp changes subtle but real: About 6 weeks into my CJC-1295 DAC protocol and the compound is doing what it is supposed to. Sleep is deeper, skin quality is better, fat around the midsection is slowly reducing, and my recovery from training is improved. The key insight I have learned is patience. This is not an overnight transformation. It is a slow, steady optimization that compounds over weeks and months. People who quit after 2 weeks are not giving it enough time. Only downsides: some mild joint stiffness early on (actually a sign it is working) and the fasted dosing schedule is sometimes inconvenient. Worth it for th
- brett24 rated it 4/5 - Slow but steady recovery was the real win: I ran CJC-1295 DAC for about 8 weeks while still trying to train around old firefighter aches and busted sleep from early starts. The main thing I noticed was recovery felt a bit easier, like I could hit the next session less cooked. Small caveat, I held a bit more water, which was annoying.
- weekendyuki rated it 4/5 - steadier weeks, but my sleep got a bit weird: i tried cjc-1295 dac for about 4 weeks because my clinic days in manila had me dragging after late charting and early lifts, basically i wanted something simple, once weekly, that fit a busy schedule. for me it seemed to make recovery a bit smoother and my training days felt less mashed up. the small caveat, my sleep got a little too deep and odd on some nights, like vivid dreams and waking heavy. still, i kept it at 4 stars.
- dose_math_derek rated it 5/5 - Sleep quality improvement was the first thing I noticed: Running CJC-1295 DAC for 1 month now, primarily for recovery and body composition. The first benefit I noticed was dramatically better sleep, deeper and more restorative, within the first week. Body composition changes came slower but are real. Leaner midsection, slightly fuller muscles, and my recovery between training sessions is noticeably improved. Not dramatic bodybuilder gains, more like everything works a bit better. Side effects have been minimal. Some water retention in the first 2 weeks that settled down, and occasional numbness in my fingers in the morning that goes away within an
- tara_n rated it 5/5 - Quietly pushed my recovery, but appetite went mad: I tried CJC-1295 DAC for 4 weeks because with startup work and lifting in India, I wanted the once weekly convenience more than anything. For me it seemed to help recovery and training consistency a lot, but my appetite got annoyingly high and I was eating more than I planned 😅
Compare CJC-1295 DAC
Research and educational reference only. Not medical advice.