Colostrum (Bovine Colostrum (IgG-Rich))

Category: Gut Health. Status: Dietary supplement (GRAS).

The first milk produced after birth, rich in immunoglobulins (IgG), growth factors (IGF-1, TGF-β), lactoferrin, and proline-rich polypeptides. Supports gut barrier integrity, immune function, and mucosal healing.

How it works

IgG antibodies bind gut pathogens and endotoxins. Growth factors (EGF, TGF-β) stimulate epithelial cell proliferation and repair. Proline-rich polypeptides modulate Th1/Th2 balance for immune regulation.

Key facts

• Molecular weight: Complex mixture
• Half-life: IgG: ~2-4 hours in GI tract
• Bioavailability: Oral - IgG survives gastric acid (~25-30%); growth factors act locally
• Storage: Room temperature (powder). Refrigerate after opening.

Dosing overview

• Typical dose: 5-20 g powder or 500-2000 mg capsules
• Frequency: Daily on empty stomach
• Duration: Ongoing or 8-12 week cycles
• Route: Oral (powder or capsule)

Reported benefits

• Gut barrier repair
• IgG immune support
• Reduced gut inflammation
• Athletic recovery
• Reduced upper respiratory infections
• Growth factor delivery

Possible side effects

• Mild bloating initially
• Dairy sensitivity (contains lactose)
• GI discomfort (initial)
• Rare allergic reaction

Research

• Bovine colostrum and intestinal permeability (2021): Reduced NSAID-induced intestinal permeability by 80% vs placebo in healthy volunteers (3-fold protective effect).
• Colostrum and athletic performance (2020): 20g/day for 8 weeks increased lean mass by 1.5kg and reduced upper respiratory illness incidence by 50% in elite athletes.

Compare Colostrum

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Community discussions about Colostrum

• BPC-157 oral dosing around physio for chronic shoulder impingement – any timing tips? - 3 comments
• Ask the community about Colostrum

Research and educational reference only. Not medical advice.