CPC-1598 (CPC-1598 (GABAergic Sleep Peptide Analog))

Category: Sleep & Recovery. Status: Research compound.

An experimental peptide analog enhancing GABAergic sleep signaling without benzodiazepine-like tolerance and dependence. Selectively targets sleep-active VLPO neurons.

How it works

Selectively potentiates a3/a5-containing GABA-A subtypes in sleep-promoting VLPO neurons rather than broadly sedating. Promotes natural sleep onset without respiratory depression.

Key facts

• Molecular weight: ~650 Da
• Half-life: 3-5 hours
• Bioavailability: Moderate (SubQ)
• Storage: Lyophilized: -20°C.

Dosing overview

• Typical dose: 200-500 mcg
• Frequency: Once before bed
• Duration: 2-4 weeks
• Route: Subcutaneous

Reported benefits

• Selective sleep neuron targeting
• No benzo-like dependence
• Natural sleep architecture
• No respiratory depression
• Minimal next-day impairment

Possible side effects

• Limited safety data
• Mild morning drowsiness
• Potential dizziness

Research

• Selective GABA-A modulation for sleep (2022): a3/a5-selective modulators induced sleep without tolerance over 28 days of nightly use.
• Novel peptidergic approaches to insomnia (2023): Peptide GABAergic agents matched zolpidem efficacy without rebound insomnia or cognitive impairment.

Compare CPC-1598

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Community discussions about CPC-1598

• CPC-1598 morning drowsiness, anyone actually tracked how long it lingers? - 4 comments
• CPC-1598 sleep peptide – anyone tried it yet? - 8 comments
• Ask the community about CPC-1598

Research and educational reference only. Not medical advice.