Gonadorelin (Gonadorelin (GnRH Analog))
A synthetic analog of gonadotropin-releasing hormone used diagnostically and therapeutically. Stimulates pulsatile LH and FSH release to maintain natural hormone production.
How it works
Binds GnRH receptors on pituitary gonadotrophs to stimulate LH and FSH release, maintaining testicular/ovarian function and natural sex hormone production.
Key facts
- Molecular weight: 1182.39 Da
- Half-life: ~10-40 minutes
- Bioavailability: ~90% subcutaneous
- Storage: Lyophilized: 2-8°C. Reconstituted: 2-8°C for up to 14 days.
Dosing overview
- Typical dose: 100-500 mcg
- Frequency: 2-3x per week or pulsatile
- Duration: 4-12 weeks
- Route: Subcutaneous injection
Reported benefits
- Maintains natural hormone production
- Fertility preservation
- Testicular function support
- LH/FSH normalization
Possible side effects
- Injection site reaction
- Headache
- Nausea
- Hot flashes
Research
- GnRH analogs for fertility preservation (2020): Maintained spermatogenesis and testicular volume in men using testosterone replacement therapy.
- Pulsatile GnRH in hypothalamic amenorrhea (2018): Restored ovulation in 85% of women with functional hypothalamic amenorrhea.
Compare Gonadorelin
Community discussions about Gonadorelin
- Looking for feedback on my NR + Kisspeptin-10 + Gonadorelin stack dosing and timing - 5 comments
- How do I work out the dose from a 5mg NR vial for a beginner stack? - 8 comments
- Anyone notice hot flashes or headaches on Gonadorelin? - 7 comments
- Managing Injection Site Reactions with Gonadorelin - 4 comments
- Gonadorelin Addition to KLOW Stack - 4 comments
- Ask the community about Gonadorelin
Research and educational reference only. Not medical advice.