Hyaluronic Acid (Hyaluronic Acid (Sodium Hyaluronate))
A naturally occurring glycosaminoglycan that holds large amounts of water, giving skin volume and hydration and cushioning joints. Used topically, orally, and as an injectable filler for skin plumping and joint support.
How it works
Hyaluronic acid binds up to ~1000 times its weight in water, hydrating and plumping the dermal matrix. It supports fibroblast function, tissue repair, and joint lubrication, and its effects depend on molecular weight (low vs high).
Key facts
- Molecular weight: Varies widely (kDa to MDa)
- Half-life: Hours to days (tissue turnover)
- Bioavailability: Topical (surface), oral (systemic), or injectable (local)
- Storage: Room temperature; refrigerate serums to extend shelf life.
Dosing overview
- Typical dose: Topical serum, ~120-240 mg/day oral, or injectable (provider)
- Frequency: 1-2x daily (topical/oral)
- Duration: Ongoing
- Route: Topical, oral, or injection
Protocol notes
- Topical: apply serum to damp skin, then seal with a moisturizer to lock in hydration.
- Oral: ~120-240 mg/day is commonly studied for skin hydration and joint comfort.
- Injectable dermal fillers must be administered by a trained provider.
Reported benefits
- Deep skin hydration and plumping
- Reduced appearance of fine lines
- Joint lubrication and comfort
- Supports wound healing
- Improves skin elasticity
Possible side effects
- Rare irritation (topical)
- Injection bruising/swelling (filler)
- Very rare allergic reaction
Research
- Oral hyaluronic acid and skin hydration (2021): Oral supplementation improved skin moisture and reduced wrinkle depth in controlled trials.
- Hyaluronic acid for joint comfort (2019): Supported joint lubrication and symptom relief in osteoarthritis studies.
Compare Hyaluronic Acid
Research and educational reference only. Not medical advice.