KPV (Lysine-Proline-Valine Tripeptide)
A tripeptide derived from alpha-MSH with potent anti-inflammatory properties. Shows promise for gut inflammation, skin conditions, and immune modulation without melanogenic effects.
How it works
Inhibits NF-kB signaling pathway, reduces pro-inflammatory cytokine production (TNF-α, IL-6), and modulates immune cell activation.
Key facts
- Molecular weight: 342.43 Da
- Half-life: ~2-3 hours
- Bioavailability: ~60-70% oral; higher subcutaneous
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for up to 21 days.
Dosing overview
- Typical dose: 200-500 mcg per dose
- Frequency: 1-2x daily
- Duration: 4-8 weeks
- Route: Oral, topical, or subcutaneous
Protocol notes
- Gut/inflammation goals: 200-500 mcg orally 1-2x daily, often on an empty stomach.
- Skin/topical use: applied in a cream or as a localized subcutaneous dose.
- Commonly paired with BPC-157 for gut-healing stacks.
Reported benefits
- Potent anti-inflammatory
- Gut inflammation reduction
- Skin condition improvement
- Immune modulation
Possible side effects
- Mild drowsiness
- Injection site reaction
- Transient flushing
Research
- KPV anti-inflammatory effects in colitis models (2021): Significantly reduced colonic inflammation and improved histological scores in IBD animal models.
- Alpha-MSH derived peptides in skin inflammation (2019): Demonstrated reduction in inflammatory markers without melanotropic activity.
Compare KPV
Community discussions about KPV
- Thoughts on combining GHK-Cu and KPV for systemic inflammation? - 4 comments
- Thinking about adding KPV to my GLOW stack for systemic inflammation? - 4 comments
- Thoughts on modifying the klow stack for tendon issues - 1 comments
- Layering vip and klow stack for systemic inflammation? - 4 comments
- Anyone notice HDL dip or liver tweaks on low-dose Oxandrolone? - 4 comments
- Ask the community about KPV
Research and educational reference only. Not medical advice.