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Lactoferrin (Lactoferrin (Iron-Binding Glycoprotein))

Category: Immune Support. Status: Dietary supplement (GRAS).

A multifunctional iron-binding glycoprotein found in milk and mucosal secretions with broad antimicrobial, anti-inflammatory, and immunomodulatory activities.

How it works

Sequesters iron from pathogens (bacteriostatic), directly disrupts bacterial membranes, activates NK cells and macrophages, and modulates inflammatory cytokines.

Key facts

  • Molecular weight: 80000 Da
  • Half-life: ~4-8 hours (oral absorption of fragments)
  • Bioavailability: ~15-25% (oral, as bioactive fragments)
  • Storage: Room temperature, protect from moisture. Refrigerate after opening.

Dosing overview

  • Typical dose: 200-600 mg
  • Frequency: 1-2x daily
  • Duration: 4-12 weeks
  • Route: Oral capsule or powder

Protocol notes

  • General immune/gut support: 200-300 mg once daily.
  • Higher targeted protocols use up to 600 mg/day, often split into two doses.
  • Apo-lactoferrin (iron-free) is preferred when the goal is antimicrobial/iron-sequestering activity.

Reported benefits

  • Broad antimicrobial activity
  • Iron homeostasis regulation
  • Gut immune support
  • Anti-biofilm properties
  • Prebiotic effects

Possible side effects

  • Mild GI discomfort
  • Constipation (iron-related)
  • Rare allergic reaction (dairy)

Research

  • Lactoferrin supplementation for immune health (2020): Reduced incidence and duration of respiratory infections by 40% in elderly subjects over 3 months.
  • Lactoferrin gut-immune axis modulation (2021): Enhanced secretory IgA production and improved gut barrier function in randomized controlled trial.

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Research and educational reference only. Not medical advice.