LSZ (Lysergic acid 2,4-dimethylazetidide)

Category: Psychedelics. Status: Schedule I (research compound).

A rigid LSD analog created to study the shape of the LSD molecule at its receptor. Effects are very LSD-like with a slightly shorter duration.

How it works

Activates serotonin 5-HT2A receptors; designed to lock the molecule into one shape.

Key facts

• Molecular weight: 349.47 g/mol
• Half-life: ~3-4 hours
• Bioavailability: Oral
• Storage: Research/reference only.

Dosing overview

• Typical dose: Varies by individual and setting
• Frequency: Occasional
• Duration: Acute effects last 6-10 hours
• Route: Oral

Protocol notes

• Taken orally on blotter or as liquid, very similar to LSD with a slightly shorter run.

Reported benefits

• Very LSD-like
• Used in receptor research
• Strong visuals
• Lysergamide research compound

Possible side effects

• Anxiety
• Raised heart rate
• Body load
• Limited human data

Compare LSZ

• LSZ vs MDMA
• LSZ vs Psilocybin
• LSZ vs LSD
• LSZ vs Ibogaine
• LSZ vs DMT
• LSZ vs Ayahuasca

Community discussions about LSZ

• LSZ – LSD‑Analog That Might Be Too Good to Be True? - 3 comments
• Ask the community about LSZ

Research and educational reference only. Not medical advice.