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Melanotan II (Melanotan II (MT-II))

Category: Sexual Health. Status: Research compound.

A synthetic cyclic alpha-MSH analog with potent melanocortin activity. Known for tanning and sexual function effects through MC1R/MC3R/MC4R activation. Parent compound of PT-141.

How it works

Non-selective MCR agonist: MC1R produces tanning, MC3R/MC4R increase sexual arousal, MC4R suppresses appetite. Broader receptor activity than PT-141.

Key facts

  • Molecular weight: 1,024 Da
  • Half-life: 2-3 hours
  • Bioavailability: High (SubQ)
  • Storage: Lyophilized: 2-8°C. Reconstituted: 2-8°C for 30 days.

Dosing overview

  • Typical dose: 0.25-1 mg
  • Frequency: Loading: daily/EOD · then 2x weekly maintenance
  • Duration: Tanning: 2-4 wk load; then maintenance
  • Route: Subcutaneous injection

Protocol notes

  • Start very low at 0.25 mg to gauge the strong nausea response.
  • Loading: 0.25-0.5 mg daily or every other day for 1-2 weeks until desired pigmentation develops.
  • Maintenance: ~0.5-1 mg roughly twice weekly to hold the tan.
  • UV exposure is still required for the tanning effect to appear.

Reported benefits

  • Skin tanning
  • Enhanced sexual function
  • Appetite suppression
  • UV protection (melanin)
  • Libido enhancement

Possible side effects

  • Nausea (common initially)
  • Facial flushing
  • Spontaneous erections
  • Mole darkening (monitor)
  • Fatigue
  • BP increase

Research

  • Melanotan II effects on sexual function: systematic review (2020): Improved erectile function in 85% and increased desire in both sexes in controlled studies.
  • Safety concerns with unregulated melanotan use (2022): Long-term use associated with new nevi formation; dermatological monitoring recommended.

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Research and educational reference only. Not medical advice.