NA-Selank (N-Acetyl Selank (Acetylated Selank))
An acetylated form of Selank with improved stability and enhanced bioavailability. Same anxiolytic and cognitive benefits with longer duration.
How it works
Same tuftsin-derived mechanism as Selank with acetyl group providing protease resistance; modulates GABA, enhances BDNF.
Key facts
- Molecular weight: 793.91 Da
- Half-life: ~5-10 minutes (effective 4-6 hours)
- Bioavailability: ~95% intranasal
- Storage: Refrigerated 2-8°C.
Dosing overview
- Typical dose: 200-400 mcg
- Frequency: 1-2x daily
- Duration: 2-4 weeks
- Route: Intranasal spray
Protocol notes
- Typical use is 1-2 nasal sprays delivering ~200-400 mcg total per dose, once or twice daily.
- Many use it situationally for acute anxiety/focus rather than around the clock.
- The acetylated form lasts longer than regular Selank, so fewer daily doses are usually needed.
Reported benefits
- Enhanced anxiolytic effect
- Improved stability
- Better bioavailability
- Cognitive focus
- Stress resilience
Possible side effects
- Nasal irritation
- Mild sedation (rare)
- Headache
Research
- N-Acetyl peptide modifications (2019): Acetylation extended effective half-life by 3-4x and improved BBB penetration.
- Modified tuftsin analogs for anxiety (2020): NA-Selank showed 40% greater anxiolytic potency than Selank.
Community reviews of NA-Selank
- cycle_sage rated it 5/5 - Consistent improvement over 2 months: Added NA-Selank to my protocol about 2 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- careful_claire rated it 5/5 - Genuinely effective after 3 months: Been using NA-Selank for about 3 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- morning_pin_maya rated it 4/5 - Worth adding to the protocol: NA-Selank has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- data_driven_dan rated it 5/5 - Solid compound with real results: Been using NA-Selank for about 1 month and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- steady_state_stan rated it 5/5 - Noticed clear benefits within weeks: Added NA-Selank to my protocol about 4 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- early_chemist rated it 5/5 - Took the edge off my Monday clinic nerves: As a yoga instructor in the UK, I was getting properly wound up before teaching early classes, even though I am usually fairly steady. I tried NA-Selank for about 6 weeks because I wanted something that might smooth that jittery, over-alert feeling without blunting me. Anecdotally, it seemed to do exactly that. I felt calmer walking into class, and my focus during sequencing was cleaner. Could be placebo, but I was chuffed with the result.
Compare NA-Selank
Research and educational reference only. Not medical advice.