Omega-3 (EPA/DHA) (Omega-3 Fatty Acids (EPA + DHA))
Essential polyunsaturated fatty acids that form the backbone of anti-inflammatory signaling. EPA and DHA reduce triglycerides, stabilize cardiac rhythm, reduce platelet aggregation, and resolve chronic inflammation through specialized pro-resolving mediators (SPMs).
How it works
EPA/DHA incorporate into cell membranes, displacing arachidonic acid and reducing pro-inflammatory eicosanoid production. Generate resolvins and protectins for active inflammation resolution. Activate PPARγ and inhibit NF-κB.
Key facts
- Molecular weight: EPA: 302.45 Da, DHA: 328.49 Da
- Half-life: ~48-72 hours (membrane incorporation)
- Bioavailability: Triglyceride form: ~70%; ethyl ester: ~30-40%; phospholipid (krill): ~85%
- Storage: Refrigerate after opening. Protect from light and oxidation.
Dosing overview
- Typical dose: 2-4g combined EPA+DHA
- Frequency: Daily with meals
- Duration: Ongoing
- Route: Oral (softgel, liquid)
Reported benefits
- Triglyceride reduction (25-45%)
- Anti-inflammatory (SPM production)
- Cardiac rhythm stabilization
- Brain and cognitive support
- Joint inflammation reduction
- Membrane fluidity optimization
Possible side effects
- Fishy aftertaste/burping
- Mild GI discomfort
- Increased bleeding time
- Rare: LDL elevation (DHA)
Research
- REDUCE-IT: Icosapent ethyl and CV events (2019): High-dose EPA (4g/day) reduced cardiovascular events by 25% in statin-treated patients with elevated triglycerides.
- Omega-3 and inflammation resolution (2021): 3g/day EPA+DHA increased specialized pro-resolving mediators (resolvins) by 3-fold, accelerating inflammation resolution.
Compare Omega-3 (EPA/DHA)
Research and educational reference only. Not medical advice.