Bergamot Extract vs Omega-3 (EPA/DHA)
A side-by-side research comparison of Bergamot Extract and Omega-3 (EPA/DHA) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Bergamot Extract | Omega-3 (EPA/DHA) |
|---|---|---|
| Full name | Citrus Bergamia Polyphenol Extract | Omega-3 Fatty Acids (EPA + DHA) |
| Category | Cardiovascular | Cardiovascular |
| Status | Dietary supplement | Dietary supplement / FDA-approved (Rx fish oil) |
| Mechanism | Polyphenolic flavonoids (brutieridin, melitidin) inhibit HMG-CoA reductase (same target as statins). Activates AMPK for fat oxidation. Reduces PCSK9 expression. Improves LDL receptor recycling for enhanced cholesterol clearance. | EPA/DHA incorporate into cell membranes, displacing arachidonic acid and reducing pro-inflammatory eicosanoid production. Generate resolvins and protectins for active inflammation resolution. Activate PPARγ and inhibit NF-κB. |
| Molecular weight | Complex polyphenol mixture | EPA: 302.45 Da, DHA: 328.49 Da |
| Half-life | ~4-6 hours | ~48-72 hours (membrane incorporation) |
| Bioavailability | ~15-25% (polyphenol absorption) | Triglyceride form: ~70%; ethyl ester: ~30-40%; phospholipid (krill): ~85% |
| Typical dose | 500-1000 mg standardized extract | 2-4g combined EPA+DHA |
| Frequency | Daily with meals | Daily with meals |
| Route | Oral capsule | Oral (softgel, liquid) |
Bergamot Extract reported benefits
- LDL cholesterol reduction (20-35%)
- HDL improvement
- Blood glucose stabilization
- Triglyceride reduction
- Statin alternative/adjunct
- No muscle pain side effects
Omega-3 (EPA/DHA) reported benefits
- Triglyceride reduction (25-45%)
- Anti-inflammatory (SPM production)
- Cardiac rhythm stabilization
- Brain and cognitive support
- Joint inflammation reduction
- Membrane fluidity optimization
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Research and educational reference only. Not medical advice.