ResearchSafe

Oxymetholone (Oxymetholone (Anadrol))

Category: Anabolic Steroids. Status: FDA-approved drug (controlled substance).

A potent oral DHT-derived anabolic steroid (Anadrol), prescribed for anemia and muscle wasting and known in bodybuilding for rapid mass and strength gains with significant water retention. Educational reference only.

How it works

Oxymetholone is a 17-alpha-alkylated derivative of DHT that strongly stimulates erythropoiesis and protein synthesis. Despite its DHT origin, it can produce estrogen-like effects through a non-aromatizing mechanism, contributing to water retention.

Key facts

  • Molecular weight: 332.5 Da
  • Half-life: ~8-9 hours
  • Bioavailability: Oral
  • Storage: Room temperature; keep dry.

Dosing overview

  • Typical dose: Medical: ~1-5 mg/kg/day for anemia
  • Frequency: Daily
  • Duration: Short courses
  • Route: Oral tablet

Protocol notes

  • Medically dosed by weight for anemia and wasting under supervision.
  • Produces fast strength and mass, largely with water retention.
  • Highly hepatotoxic; short courses only.

Reported benefits

  • Rapid mass and strength
  • Strong red blood cell stimulation
  • Treats anemia/wasting (medical)
  • Increased appetite

Possible side effects

  • High liver toxicity
  • Water retention/bloating
  • Blood pressure elevation
  • Estrogen-like effects (gyno)
  • Testosterone suppression
  • Adverse lipids

Research

  • Oxymetholone in anemia and wasting (2015): Increased hemoglobin and lean body mass in anemic and HIV-wasting patients under monitoring.

Community reviews of Oxymetholone

Rated 5 out of 5 from 4 community reviews by ResearchSafe members.

  • bio_optimal rated it 5/5 - Genuinely effective after 2 weeks: Been using Oxymetholone for about 2 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
  • biohack_bree rated it 5/5 - Worth adding to the protocol: Oxymetholone has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
  • bio_optimal rated it 5/5 - Noticed clear benefits within weeks: Added Oxymetholone to my protocol about 2 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
  • peptide_path_pam rated it 5/5 - Solid compound with real results: Been using Oxymetholone for about 6 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.

Compare Oxymetholone

Community discussions about Oxymetholone

Research and educational reference only. Not medical advice.