Palmitoyl Tripeptide-1 (Palmitoyl Tripeptide-1 (Pal-GHK))
A lipopeptide acting as a matrikine, signaling skin repair by mimicking collagen breakdown products that trigger fibroblast collagen production.
How it works
Functions as matrikine signal, mimicking collagen fragments that trigger fibroblasts to produce new collagen. Palmitoyl enables deeper skin penetration.
Key facts
- Molecular weight: 578.8 Da
- Half-life: 8-12 hours (topical)
- Bioavailability: Good (topical with lipid modification)
- Storage: Room temperature, stable in formulation.
Dosing overview
- Typical dose: 2-5% in formulation
- Frequency: 1-2x daily
- Duration: 8-16 weeks
- Route: Topical
Reported benefits
- Collagen synthesis stimulation
- Matrix remodeling
- Wrinkle reduction
- Skin thickness increase
Possible side effects
- Very well tolerated
- Rare irritation
Research
- Matrikine signaling by Pal-GHK in aged skin (2021): Increased collagen I gene expression by 150% and reduced MMP-1 by 40% in photodamaged skin.
- Pal-GHK and Pal-GQPR combination (Matrixyl 3000) (2020): Reduced wrinkle volume by 44% and improved skin tone by 26% over 8 weeks.
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Community discussions about Palmitoyl Tripeptide-1
- Seeing real skin changes after 6 months of Matrixyl use - 3 comments
- Matrixyl 3000 actually worth it or just expensive moisturiser in a fancy bottle? - 4 comments
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Research and educational reference only. Not medical advice.