SNAP-25 Fragment (SNAP-25 Inhibitory Fragment Peptide)
A targeted fragment peptide designed to specifically disrupt SNARE complex assembly for expression wrinkle reduction. Newer generation of neuromuscular anti-wrinkle peptides.
How it works
Directly competes with the SNAP-25 binding domain in SNARE complex formation, providing highly specific inhibition of vesicle fusion at facial neuromuscular junctions.
Key facts
- Molecular weight: ~650 Da
- Half-life: N/A (topical depot)
- Bioavailability: Topical penetration ~6-9%
- Storage: Room temperature, protect from heat.
Dosing overview
- Typical dose: 3-8% in formulation
- Frequency: 2x daily
- Duration: 4-8 weeks
- Route: Topical serum
Protocol notes
- Used as a topical serum containing ~3-8% of the peptide, applied to expression-line areas (forehead, crow's feet).
- Apply morning and night to clean, dry skin; let it absorb before other products.
- Often layered with Argireline/SNAP-8 for complementary expression-line softening.
Reported benefits
- Highly specific SNARE targeting
- Expression line reduction
- Improved selectivity
- Complementary to Argireline
Possible side effects
- Mild tingling
- Rare irritation
- Temporary tightness
Research
- Next-generation SNARE-targeting peptides (2020): Demonstrated improved specificity for facial muscle relaxation vs first-generation SNAP-25 competitors.
- Fragment-based approach to cosmetic peptides (2021): Smaller fragment size improved dermal penetration by 40% vs full-length competitors.
Compare SNAP-25 Fragment
Community discussions about SNAP-25 Fragment
- Thoughts on SNAP-25 vs Argireline for expression lines? - 4 comments
- Mild tingling from SNAP-25 fragment peptide – anyone else? - 4 comments
- Ask the community about SNAP-25 Fragment
Research and educational reference only. Not medical advice.