Tadalafil (Tadalafil (Cialis))
A long-acting PDE5 inhibitor prescribed by telemedicine clinics for erectile dysfunction and daily low-dose cardiovascular/prostate health. Its 36-hour duration of effect earned it the nickname "the weekend pill." Also used for pulmonary hypertension and BPH.
How it works
Selectively inhibits phosphodiesterase type 5 (PDE5), preventing cGMP breakdown in smooth muscle. This enhances nitric oxide signaling for vasodilation in penile, pulmonary, and prostate tissue.
Key facts
- Molecular weight: 389.40 Da
- Half-life: ~17.5 hours
- Bioavailability: ~36% oral
- Storage: Room temperature.
Dosing overview
- Typical dose: 2.5-5 mg daily or 10-20 mg as needed
- Frequency: Daily or on-demand
- Duration: Ongoing
- Route: Oral tablet
Protocol notes
- Daily approach: 2.5-5 mg every day for steady readiness plus the cardiovascular/prostate benefits.
- On-demand approach: 10-20 mg taken at least 30-60 minutes before activity (works for up to ~36 hours).
- Pick one approach - don't combine daily dosing with large on-demand doses.
Reported benefits
- Erectile function improvement
- Cardiovascular health (vasodilation)
- Prostate health (BPH)
- Improved exercise capacity
- Nitric oxide support
Possible side effects
- Headache
- Back pain
- Muscle aches
- Nasal congestion
- Flushing
- Indigestion
Research
- Daily tadalafil and endothelial function (2022): Daily 5mg tadalafil improved flow-mediated dilation by 30% and reduced arterial stiffness in men over 12 weeks.
Compare Tadalafil
Community discussions about Tadalafil
- Tadalafil‑Peptide: personal experience and questions on side‑effects - 6 comments
- Seeking input on an Alpha‑Lipoic Acid + TUDCA recovery stack with a low‑dose Tadalafil twist? - 12 comments
- Tbh the new tadalafil‑peptide conjugate: hype vs real benefits? - 5 comments
- "Layering Tadalafil daily with ALA and TUDCA, overkill or actually sensible?" - 4 comments
- Confused about tadalafil vs the peptide conjugate version, which one should I look into first? - 4 comments
- Ask the community about Tadalafil
Research and educational reference only. Not medical advice.