Tesofensine (Tesofensine (Triple Monoamine Reuptake Inhibitor))
A triple monoamine reuptake inhibitor that blocks norepinephrine, serotonin, and dopamine reuptake, producing significant appetite suppression and increased metabolic rate.
How it works
Blocks presynaptic reuptake of noradrenaline, dopamine, and serotonin in the hypothalamus, enhancing satiety signaling, reducing food reward, and increasing thermogenesis.
Key facts
- Molecular weight: 329.4 Da
- Half-life: 8-10 days
- Bioavailability: High (oral ~93%)
- Storage: Room temperature, protected from light and moisture.
Dosing overview
- Typical dose: 0.25-0.5 mg
- Frequency: Once daily
- Duration: 24+ weeks
- Route: Oral
Reported benefits
- Significant appetite reduction
- Increased metabolic rate
- Improved satiety signaling
- 10-12% body weight loss
- Oral administration convenience
Possible side effects
- Dry mouth
- Insomnia
- Increased heart rate
- Elevated blood pressure
- Constipation
- Mood changes
Research
- TEMPO Phase 2b: Tesofensine for obesity (2020): Tesofensine 0.5mg produced 10.6% weight loss vs 2.0% placebo at 24 weeks.
- Cardiovascular safety profile of tesofensine (2021): Heart rate increases were dose-dependent and manageable at 0.25mg; blood pressure changes minimal.
Compare Tesofensine
Community discussions about Tesofensine
- My 6‑week tesofensine run – appetite, weight, and side notes - 7 comments
- Combining Tesofensine with GLOW for weight loss & skin recovery – thoughts? - 4 comments
- First steps with Tesofensine – dose, timing, and side‑effect worries - 4 comments
- Tesofensine half-life and stacking with a healing protocol, how do you manage overlap? - 3 comments
- My 6‑week Tesofensine trial – appetite HRV and side‑effects log - 4 comments
- Ask the community about Tesofensine
Research and educational reference only. Not medical advice.