ResearchSafe

Tesofensine (Tesofensine (Triple Monoamine Reuptake Inhibitor))

Category: Weight Management. Status: Phase 3 Clinical Trial.

A triple monoamine reuptake inhibitor that blocks norepinephrine, serotonin, and dopamine reuptake, producing significant appetite suppression and increased metabolic rate.

How it works

Blocks presynaptic reuptake of noradrenaline, dopamine, and serotonin in the hypothalamus, enhancing satiety signaling, reducing food reward, and increasing thermogenesis.

Key facts

  • Molecular weight: 329.4 Da
  • Half-life: 8-10 days
  • Bioavailability: High (oral ~93%)
  • Storage: Room temperature, protected from light and moisture.

Dosing overview

  • Typical dose: 0.25-0.5 mg
  • Frequency: Once daily
  • Duration: 24+ weeks
  • Route: Oral

Reported benefits

  • Significant appetite reduction
  • Increased metabolic rate
  • Improved satiety signaling
  • 10-12% body weight loss
  • Oral administration convenience

Possible side effects

  • Dry mouth
  • Insomnia
  • Increased heart rate
  • Elevated blood pressure
  • Constipation
  • Mood changes

Research

  • TEMPO Phase 2b: Tesofensine for obesity (2020): Tesofensine 0.5mg produced 10.6% weight loss vs 2.0% placebo at 24 weeks.
  • Cardiovascular safety profile of tesofensine (2021): Heart rate increases were dose-dependent and manageable at 0.25mg; blood pressure changes minimal.

Community reviews of Tesofensine

Rated 4.6 out of 5 from 16 community reviews by ResearchSafe members.

  • research_marcus rated it 5/5 - Worth adding to the protocol: Tesofensine has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
  • cycle_sage rated it 5/5 - Noticed clear benefits within weeks: Added Tesofensine to my protocol about 3 weeks ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
  • halflife_harry rated it 4/5 - Genuinely effective after 6 months: Been using Tesofensine for about 6 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
  • biohacker_retired rated it 4/5 - Knocked Out My Cravings, Dropped 20 lbs Fast: I wanted something strong for appetite, and tesofensine definitely hit that for me – food basically stopped being interesting after the first week. Lost about 20 lbs over three months, which kinda blew my mind to be fair. I had some dry mouth and weird sleep the first couple weeks, but my body adjusted. I’d do it again for cutting, just gotta watch for the stim edge if you’re sensitive.
  • recovery_midwest rated it 4/5 - 10 weeks, less snacking on the night shift: i tried tesofensine because my grad school nights on the east coast had turned into way too many late snacks, and that creeping 50-something belly was bugging me more than i wanted to admit. over about 10 weeks i dropped 14 lbs, mostly because i just stopped thinking about food all day. the only caveat for me was a little wired feeling if i took it too late πŸ™Œ
  • frugal_fasted rated it 4/5 - Tesofensine made cutting in Dublin a lot less grim: I ran tesofensine for about 12 weeks while coaching CrossFit and trying to stay lean without feeling wrecked in the gym. For me it fit grand into busy days, because I was just not as interested in snacking between sessions. I lost about 6 kg over that stretch. The caveat was that I felt a bit too wired if I took it too late, so I had to be sensible with timing.

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Community discussions about Tesofensine

Research and educational reference only. Not medical advice.