Testosterone Enanthate (Testosterone Enanthate (Long-Ester Testosterone))
A long-acting injectable ester of testosterone, one of the most widely used forms for testosterone replacement therapy (TRT) and, non-medically, as the base of most anabolic steroid cycles. Included for educational reference on its pharmacology and risks.
How it works
A testosterone molecule attached to an enanthate ester that slows release from the injection site. Once cleaved, testosterone binds androgen receptors to increase muscle protein synthesis, nitrogen retention, red blood cell production, and secondary sexual characteristics.
Key facts
- Molecular weight: 400.6 Da
- Half-life: ~4.5-5 days
- Bioavailability: Intramuscular/subcutaneous injection
- Storage: Room temperature; protect from light.
Dosing overview
- Typical dose: TRT ~100-200 mg/week (medical)
- Frequency: 1-2x weekly
- Duration: Ongoing (medical) or cycled
- Route: Intramuscular or subcutaneous injection
Protocol notes
- Medical TRT is individualized by a physician, commonly ~100-200 mg/week split into 1-2 injections.
- Supraphysiologic non-medical use carries substantially higher health risk and is often illegal without a prescription.
- Blood work (testosterone, estradiol, hematocrit, lipids) guides medical dosing.
Reported benefits
- Restores testosterone in deficiency (medical)
- Increased muscle mass and strength
- Improved libido and mood (when deficient)
- Increased bone density
- Stable long-acting levels
Possible side effects
- Suppression of natural testosterone/fertility
- Elevated hematocrit (clot risk)
- Estrogenic effects (gyno, water retention)
- Acne and oily skin
- Adverse lipid/cardiovascular effects
- Testicular atrophy
Research
- Testosterone therapy in hypogonadism (2018): Restored physiological testosterone and improved lean mass, libido, and bone density in deficient men under monitoring.
Compare Testosterone Enanthate
Research and educational reference only. Not medical advice.