Thymulin (Thymulin (Facteur Thymique Serique))
A zinc-dependent nonapeptide secreted by thymic epithelial cells that is essential for T-cell differentiation. Levels decline dramatically with thymic involution during aging.
How it works
Binds to specific receptors on T-cell precursors promoting their differentiation into mature T-cells, modulates cytokine production, and requires zinc as cofactor.
Key facts
- Molecular weight: 847.9 Da
- Half-life: ~2 hours
- Bioavailability: ~80% subcutaneous
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for up to 7 days.
Dosing overview
- Typical dose: 1-5 mg
- Frequency: 2-3x per week
- Duration: 4-8 weeks
- Route: Subcutaneous injection
Reported benefits
- T-cell maturation support
- Thymic function restoration
- Zinc-dependent immune activation
- Anti-inflammatory properties
Possible side effects
- Injection site reaction
- Mild fatigue
- Transient joint aches
Research
- Thymulin in immune reconstitution (2018): Restored T-cell subset ratios and improved vaccine responses in zinc-supplemented elderly subjects.
- Thymic peptides and aging immunity (2020): Demonstrated partial reversal of age-related thymic involution markers with regular supplementation.
Compare Thymulin
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Research and educational reference only. Not medical advice.