1P-LSD vs Ibogaine
A side-by-side research comparison of 1P-LSD and Ibogaine across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | 1P-LSD | Ibogaine |
|---|---|---|
| Full name | 1-Propionyl-LSD | Ibogaine (from Tabernanthe iboga) |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Schedule I (research compound) |
| Mechanism | Likely acts as a prodrug for LSD, activating serotonin 5-HT2A receptors. | Acts on multiple systems at once, including serotonin and opioid receptors, NMDA receptors and nicotinic receptors. Its active metabolite noribogaine is thought to drive much of the lasting anti-addiction effect. |
| Molecular weight | 379.50 g/mol | 310.43 g/mol |
| Half-life | ~3-5 hours | ~4-7 hours (ibogaine); noribogaine much longer |
| Bioavailability | Oral | Oral |
| Typical dose | Varies by individual and setting | Weight-based, given in specialized clinics |
| Frequency | Occasional | Usually a single session |
| Route | Oral | Oral, under medical and cardiac monitoring |
1P-LSD reported benefits
- Nearly identical to LSD
- Used as a research LSD analog
- Long, classic psychedelic experience
- Well-known harm-reduction profile
Ibogaine reported benefits
- Studied for opioid use disorder
- Can reduce withdrawal symptoms quickly
- May lower cravings after a single session
- Investigated for traumatic brain injury (with magnesium) in veterans
Related comparisons
Research and educational reference only. Not medical advice.