ResearchSafe

1P-LSD (1-Propionyl-LSD)

Category: Psychedelics. Status: Schedule I (research compound).

A close chemical relative of LSD that the body appears to convert back into LSD, giving a near-identical experience. Widely used in research as a legal-gray-area LSD alternative in some regions.

How it works

Likely acts as a prodrug for LSD, activating serotonin 5-HT2A receptors.

Key facts

  • Molecular weight: 379.50 g/mol
  • Half-life: ~3-5 hours
  • Bioavailability: Oral
  • Storage: Research/reference only.

Dosing overview

  • Typical dose: Varies by individual and setting
  • Frequency: Occasional
  • Duration: Acute effects last 8-12 hours
  • Route: Oral

Protocol notes

  • Taken orally on blotter or as liquid, almost identical to LSD in use and duration.
  • People clear their day because effects last 8-12 hours.

Reported benefits

  • Nearly identical to LSD
  • Used as a research LSD analog
  • Long, classic psychedelic experience
  • Well-known harm-reduction profile

Possible side effects

  • Long, intense experiences
  • Anxiety or fear
  • Raised heart rate and blood pressure
  • Visual distortions for hours

Compare 1P-LSD

Research and educational reference only. Not medical advice.