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DHEA (Dehydroepiandrosterone)

Category: Hormone Replacement. Status: OTC supplement / Prescribed.

A naturally occurring hormone precursor produced by the adrenal glands. Levels decline significantly with age. Commonly prescribed by telemedicine clinics as part of hormone optimization protocols.

How it works

Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism.

Key facts

  • Molecular weight: 288.42 Da
  • Half-life: 15-38 hours
  • Bioavailability: ~100% oral
  • Storage: Room temperature.

Dosing overview

  • Typical dose: 25-100 mg
  • Frequency: Daily (morning)
  • Duration: Ongoing with monitoring
  • Route: Oral capsule or topical cream

Protocol notes

  • Men often use 25-100 mg/day; women typically use much lower doses (~5-25 mg) due to androgenic effects.
  • Start low (e.g. 25 mg) and adjust based on DHEA-S bloodwork rather than guessing.
  • Topical cream is an option when oral causes acne/oily skin.

Reported benefits

  • Hormone precursor support
  • Improved energy levels
  • Bone density support
  • Cognitive function
  • Immune enhancement
  • Anti-aging

Possible side effects

  • Acne
  • Hair loss (androgenic)
  • Mood changes
  • Oily skin
  • Hormonal imbalance if overdosed

Research

  • DHEA supplementation in aging adults (2020): Restored youthful DHEA-S levels and improved bone mineral density, lean mass, and well-being scores.
  • Neurosteroid effects of DHEA (2021): Demonstrated neuroprotective and mood-enhancing effects through GABA-A and sigma-1 receptor modulation.

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Research and educational reference only. Not medical advice.