Apigenin (Apigenin (Flavone))
A flavone found in chamomile and parsley, popularized by longevity researchers as part of an evening sleep stack. Biohackers use it for sleep onset, relaxation, and its NAD-preserving and anti-inflammatory properties.
How it works
Binds benzodiazepine sites on GABA-A receptors for mild anxiolytic and sedative effects, and inhibits CD38, an NAD-consuming enzyme, thereby helping preserve cellular NAD+ levels. Also provides antioxidant and anti-inflammatory activity.
Key facts
- Molecular weight: 270.24 Da
- Half-life: ~5-10 hours
- Bioavailability: Low; enhanced by fat and formulation
- Storage: Room temperature, protect from light.
Dosing overview
- Typical dose: 50 mg per day
- Frequency: Once daily (evening)
- Duration: Ongoing
- Route: Oral capsule
Protocol notes
- Common sleep-stack dose is ~50 mg taken 30-60 minutes before bed.
- Often stacked with magnesium and glycine/theanine for an evening protocol.
- Taking with a little dietary fat can aid absorption.
Reported benefits
- Supports sleep onset
- Mild anxiolytic/relaxation
- CD38 inhibition (NAD+ preservation)
- Antioxidant and anti-inflammatory
- Potential anti-cancer research interest
Possible side effects
- Mild drowsiness
- Rare GI upset
- Possible additive sedation with other sleep aids
- Chamomile-allergy caution
Research
- Apigenin inhibits CD38 and preserves NAD+ (2013): Apigenin inhibited CD38, raising intracellular NAD+ and improving metabolic markers in animal models.
- Apigenin GABA-A modulation (2019): Demonstrated anxiolytic and mild sedative effects via benzodiazepine-site GABA-A binding.
Compare Apigenin
Research and educational reference only. Not medical advice.