Clomiphene Citrate vs Pregnenolone
A side-by-side research comparison of Clomiphene Citrate and Pregnenolone across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Clomiphene Citrate | Pregnenolone |
|---|---|---|
| Full name | Clomiphene Citrate (Clomid) | Pregnenolone (Mother Hormone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | FDA Approved (off-label for men) | OTC supplement / Prescribed |
| Mechanism | Blocks estrogen receptors in the hypothalamus, preventing negative feedback. This increases GnRH pulsatility, elevating pituitary LH and FSH output and subsequently testicular testosterone production. | Acts as the primary substrate for steroidogenesis (cortisol, DHEA, progesterone, testosterone, estrogen). Also functions as a neurosteroid, enhancing memory and NMDA receptor activity. |
| Molecular weight | 598.09 Da (citrate salt) | 316.48 Da |
| Half-life | ~5-7 days | ~1-3 hours (oral) |
| Bioavailability | ~80% oral | ~60% oral |
| Typical dose | 12.5-50 mg | 50-100 mg |
| Frequency | Daily or every other day | Daily (morning) |
| Route | Oral | Oral capsule or sublingual |
Clomiphene Citrate reported benefits
- Increased endogenous testosterone
- Preserved fertility
- Elevated LH/FSH
- No testicular atrophy
- Improved sperm parameters
Pregnenolone reported benefits
- Hormone precursor balance
- Memory enhancement
- Mood improvement
- Joint support
- Myelin sheath repair
- Stress resilience
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Research and educational reference only. Not medical advice.