Clomiphene Citrate (Clomiphene Citrate (Clomid))
A selective estrogen receptor modulator (SERM) used off-label in men to raise endogenous testosterone by blocking hypothalamic estrogen feedback. An alternative to TRT that preserves fertility.
How it works
Blocks estrogen receptors in the hypothalamus, preventing negative feedback. This increases GnRH pulsatility, elevating pituitary LH and FSH output and subsequently testicular testosterone production.
Key facts
- Molecular weight: 598.09 Da (citrate salt)
- Half-life: ~5-7 days
- Bioavailability: ~80% oral
- Storage: Room temperature. Protect from light and moisture.
Dosing overview
- Typical dose: 12.5-50 mg
- Frequency: Daily or every other day
- Duration: 3-6 months
- Route: Oral
Reported benefits
- Increased endogenous testosterone
- Preserved fertility
- Elevated LH/FSH
- No testicular atrophy
- Improved sperm parameters
Possible side effects
- Visual disturbances (rare)
- Mood swings
- Elevated estradiol (zuclomiphene)
- Headache
- Hot flashes
Research
- Clomiphene for male hypogonadism (2019): Increased total testosterone from 228 to 612 ng/dL over 3 months with preserved spermatogenesis in men aged 18-55.
- Long-term clomiphene safety in men (2021): 5-year follow-up showed sustained testosterone elevation without significant adverse events or bone density loss.
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Research and educational reference only. Not medical advice.