Clomiphene Citrate vs Testosterone Cypionate
A side-by-side research comparison of Clomiphene Citrate and Testosterone Cypionate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Clomiphene Citrate | Testosterone Cypionate |
|---|---|---|
| Full name | Clomiphene Citrate (Clomid) | Testosterone Cypionate (Depo-Testosterone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | FDA Approved (off-label for men) | FDA Approved (Schedule III) |
| Mechanism | Blocks estrogen receptors in the hypothalamus, preventing negative feedback. This increases GnRH pulsatility, elevating pituitary LH and FSH output and subsequently testicular testosterone production. | Exogenous testosterone binds androgen receptors in muscle, bone, brain, and reproductive tissues. The cypionate ester provides slow release from the injection depot, maintaining physiologic levels between doses. |
| Molecular weight | 598.09 Da (citrate salt) | 412.61 Da |
| Half-life | ~5-7 days | ~8 days |
| Bioavailability | ~80% oral | ~100% (intramuscular) |
| Typical dose | 12.5-50 mg | 100-200 mg |
| Frequency | Daily or every other day | Weekly or split biweekly |
| Route | Oral | Intramuscular or subcutaneous injection |
Clomiphene Citrate reported benefits
- Increased endogenous testosterone
- Preserved fertility
- Elevated LH/FSH
- No testicular atrophy
- Improved sperm parameters
Testosterone Cypionate reported benefits
- Restored libido and sexual function
- Increased lean muscle mass
- Improved bone density
- Enhanced mood and cognitive clarity
- Reduced visceral fat
- Improved energy and motivation
Related comparisons
Research and educational reference only. Not medical advice.