Dihexa vs Synapsin
A side-by-side research comparison of Dihexa and Synapsin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Dihexa | Synapsin |
|---|---|---|
| Full name | Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) | Synapsin Nasal Spray (RG3 + NAD+ + Methylcobalamin) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Compounded medication |
| Mechanism | Allosteric potentiator of HGF/c-Met signaling driving synaptogenesis, dendritic spine formation, and neuronal survival in hippocampal circuits. | Rg3 reduces neuroinflammation and protects neurons. NAD+ supports mitochondrial function and sirtuin activation in brain cells. Methylcobalamin provides methylation support and myelin repair. Nasal route bypasses BBB for direct CNS delivery. |
| Molecular weight | 507.6 Da | Combination compound |
| Half-life | 6-12 hours | Variable (nasal depot effect) |
| Bioavailability | Moderate (oral/SubQ) | ~60-80% nasal (direct CNS access) |
| Typical dose | 10-20 mg (oral) or 2-5 mg (SubQ) | 1-2 sprays per nostril |
| Frequency | Daily | 1-2x daily |
| Route | Oral or Subcutaneous | Intranasal spray |
Dihexa reported benefits
- Dramatic synaptogenesis
- Memory improvement
- Cognitive restoration potential
- Dendritic spine growth
- HGF/c-Met activation
Synapsin reported benefits
- Improved mental clarity
- Reduced brain fog
- Neuroprotection
- Enhanced focus
- Nerve repair support
- Anti-neuroinflammatory
Related comparisons
Research and educational reference only. Not medical advice.