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Synapsin (Synapsin Nasal Spray (RG3 + NAD+ + Methylcobalamin))

Category: Cognitive & Nootropic. Status: Compounded medication.

A popular telemedicine compounded nasal spray combining ginsenoside Rg3, NAD+, and methylcobalamin for cognitive enhancement. Targets neuroinflammation, cellular energy, and nerve function directly via nasal delivery to the brain.

How it works

Rg3 reduces neuroinflammation and protects neurons. NAD+ supports mitochondrial function and sirtuin activation in brain cells. Methylcobalamin provides methylation support and myelin repair. Nasal route bypasses BBB for direct CNS delivery.

Key facts

  • Molecular weight: Combination compound
  • Half-life: Variable (nasal depot effect)
  • Bioavailability: ~60-80% nasal (direct CNS access)
  • Storage: Refrigerate 2-8°C.

Dosing overview

  • Typical dose: 1-2 sprays per nostril
  • Frequency: 1-2x daily
  • Duration: Ongoing or cycled
  • Route: Intranasal spray

Protocol notes

  • Typical use is 1-2 metered sprays in each nostril, once or twice daily.
  • Prime the pump before first use; sniff gently so the spray coats the nasal mucosa rather than running down the throat.
  • Many use it in the morning for clarity, with an optional midday dose.

Reported benefits

  • Improved mental clarity
  • Reduced brain fog
  • Neuroprotection
  • Enhanced focus
  • Nerve repair support
  • Anti-neuroinflammatory

Possible side effects

  • Nasal irritation
  • Mild headache initially
  • Rare: nosebleed
  • Taste changes

Research

  • Intranasal NAD+ for cognitive function (2022): Nasal NAD+ achieved 4x higher brain tissue levels than IV administration with improved cognitive scores in TBI patients.
  • Ginsenoside Rg3 neuroprotection (2021): Rg3 reduced neuroinflammatory markers by 55% and improved memory consolidation in neurodegenerative models.

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Research and educational reference only. Not medical advice.