FGL vs N-Acetyl Selank Amidate
A side-by-side research comparison of FGL and N-Acetyl Selank Amidate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | FGL | N-Acetyl Selank Amidate |
|---|---|---|
| Full name | FGL (NCAM-Derived Peptide) | N-Acetyl Selank Amidate (NA Selank) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Mimics NCAM FG loop interacting with FGFR1 to promote LTP, neurite outgrowth, neuronal survival, and presynaptic function enhancement. | Modulates GABA and serotonin systems and influences BDNF and the expression of enkephalin-degrading enzymes, producing anti-anxiety and mood-stabilizing effects. The acetyl/amidate modifications extend its duration. |
| Molecular weight | ~1,800 Da | ~800 Da |
| Half-life | 4-8 hours | Longer than base Selank |
| Bioavailability | Moderate (SubQ, partial BBB crossing) | Intranasal (primary); subcutaneous also used |
| Typical dose | 1-5 mg/kg (research) | ~300-900 mcg per day |
| Frequency | Daily or every other day | 1-2x daily |
| Route | Subcutaneous | Intranasal spray/drops |
FGL reported benefits
- Synaptic plasticity
- LTP facilitation
- Memory improvement
- Neurotrophic effects
- FGFR activation
N-Acetyl Selank Amidate reported benefits
- Reduces anxiety without sedation
- Calm focus
- Mood support
- No reported dependence/withdrawal
Related comparisons
Research and educational reference only. Not medical advice.