FGL vs Selank
A side-by-side research comparison of FGL and Selank across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | FGL | Selank |
|---|---|---|
| Full name | FGL (NCAM-Derived Peptide) | Selank (TP-7) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Research compound |
| Mechanism | Mimics NCAM FG loop interacting with FGFR1 to promote LTP, neurite outgrowth, neuronal survival, and presynaptic function enhancement. | Modulates GABA-A allosteric sites, increases BDNF, stabilizes enkephalin degradation, and influences serotonin metabolism. Enhances IL-6 and Th1/Th2 balance. |
| Molecular weight | ~1,800 Da | 751.9 Da |
| Half-life | 4-8 hours | 3-5 min (IV) / 15-30 min (intranasal) |
| Bioavailability | Moderate (SubQ, partial BBB crossing) | Moderate (intranasal) |
| Typical dose | 1-5 mg/kg (research) | 250-750 mcg per spray dose |
| Frequency | Daily or every other day | 2-3x daily |
| Route | Subcutaneous | Intranasal spray |
FGL reported benefits
- Synaptic plasticity
- LTP facilitation
- Memory improvement
- Neurotrophic effects
- FGFR activation
Selank reported benefits
- Anxiolytic without sedation
- Improved memory/learning
- Cognitive flexibility
- Immune modulation
- BDNF upregulation
- No addiction
Related comparisons
Research and educational reference only. Not medical advice.