FGL (FGL (NCAM-Derived Peptide))
A peptide from the FG loop of neural cell adhesion molecule (NCAM). Enhances synaptic plasticity, memory, and neurotrophic effects through FGFR activation.
How it works
Mimics NCAM FG loop interacting with FGFR1 to promote LTP, neurite outgrowth, neuronal survival, and presynaptic function enhancement.
Key facts
- Molecular weight: ~1,800 Da
- Half-life: 4-8 hours
- Bioavailability: Moderate (SubQ, partial BBB crossing)
- Storage: Lyophilized: -20°C.
Dosing overview
- Typical dose: 1-5 mg/kg (research)
- Frequency: Daily or every other day
- Duration: 2-4 weeks
- Route: Subcutaneous
Reported benefits
- Synaptic plasticity
- LTP facilitation
- Memory improvement
- Neurotrophic effects
- FGFR activation
Possible side effects
- Limited data
- Theoretical mitogenic concern
- Injection site reaction
Research
- FGL enhances hippocampal LTP and memory in aged rats (2020): Restored LTP to young-adult levels and improved contextual fear memory by 45%.
- NCAM-derived peptides for cognitive enhancement (2019): Improved social memory and reduced anxiety through FGFR1-dependent synaptic modulation.
Compare FGL
Community discussions about FGL
- Trying FGL peptide for memory – any thoughts on dosing and timing? - 6 comments
- FGL injection site reaction – what worked for you? - 7 comments
- Testing lån: FGL + GLOW combo for post‑workout recovery - 4 comments
- tweaking a FGL‑GHK‑Cu combo for brain‑body recovery – need dosing feedback - 4 comments
- Feedback on combining FGL with a low‑dose KLOW for post‑run recovery - 4 comments
- Ask the community about FGL
Research and educational reference only. Not medical advice.