ResearchSafe

Selank (Selank (TP-7))

Category: Cognitive & Nootropic. Status: Research compound.

A synthetic analog of tuftsin with Pro-Gly-Pro for stability. Developed at the Russian Academy of Sciences with anxiolytic and nootropic properties without sedation or addiction.

How it works

Modulates GABA-A allosteric sites, increases BDNF, stabilizes enkephalin degradation, and influences serotonin metabolism. Enhances IL-6 and Th1/Th2 balance.

Key facts

  • Molecular weight: 751.9 Da
  • Half-life: 3-5 min (IV) / 15-30 min (intranasal)
  • Bioavailability: Moderate (intranasal)
  • Storage: Solution: 2-8°C. Protected from light.

Dosing overview

  • Typical dose: 250-750 mcg per spray dose
  • Frequency: 2-3x daily
  • Duration: 2-4 week courses
  • Route: Intranasal spray

Protocol notes

  • Delivered intranasally, split across 2-3 doses through the day.
  • Run in 2-4 week courses; commonly stacked with Semax for a calm-but-focused nootropic combo.

Reported benefits

  • Anxiolytic without sedation
  • Improved memory/learning
  • Cognitive flexibility
  • Immune modulation
  • BDNF upregulation
  • No addiction

Possible side effects

  • Nasal irritation
  • Mild fatigue (initial)
  • Headache (rare)

Research

  • Selank anxiolytic effects vs benzodiazepines (2021): Equivalent anxiolysis to diazepam in GAD without cognitive impairment or dependence over 8 weeks.
  • BDNF modulation by selank (2020): Increased hippocampal BDNF by 60% and improved spatial memory by 35% in aged models.

Community reviews of Selank

Rated 4.6 out of 5 from 11 community reviews by ResearchSafe members.

  • cycling_chad rated it 5/5 - Worth adding to the protocol: Selank has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
  • peptide_sarah rated it 5/5 - Genuinely effective after 6 months: Been using Selank for about 6 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
  • growth_factor_gabe rated it 4/5 - Noticed clear benefits within weeks: Added Selank to my protocol about 4 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
  • medic_derek rated it 4/5 - Took the edge off my exam-term head noise: I tried Selank over about 4 months because, tbh, teaching senior classes in NZ while also trying to keep my own training ticking over had my head pretty noisy and I wanted something that might calm me without flattening me. For me it seemed to take the edge off that wired, fidgety feeling, and I was a bit steadier in the afternoons, but it did not do much for memory on its own.
  • protocol_luis rated it 4/5 - Selank was calmer, but i still preferred L-theanine: I ran Selank for about 10 weeks while juggling pharmacy shifts, study bits, and training, and it did take the edge off that wired, slightly jittery feeling for me. I felt a bit more even and less snappy on busy days, which was lekker. Compared with L-theanine, though, I actually preferred theanine for quick calm and cleaner focus. Selank felt smoother overall, just a bit slower to notice, maybe a bit subtle for me 🙂
  • peptidehead_aspiring rated it 5/5 - calm focus that surprised my sceptic brain: i went in sceptical, honestly, because it sounded a bit too tidy on paper. after about 4 weeks on selank, my usual low-grade anxious buzz eased and i felt more mentally organised at the desk here in sweden, especially during long grad work days. for me, that scepticism did change. 🧠

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Community discussions about Selank

Research and educational reference only. Not medical advice.