Selank (Selank (TP-7))
A synthetic analog of tuftsin with Pro-Gly-Pro for stability. Developed at the Russian Academy of Sciences with anxiolytic and nootropic properties without sedation or addiction.
How it works
Modulates GABA-A allosteric sites, increases BDNF, stabilizes enkephalin degradation, and influences serotonin metabolism. Enhances IL-6 and Th1/Th2 balance.
Key facts
- Molecular weight: 751.9 Da
- Half-life: 3-5 min (IV) / 15-30 min (intranasal)
- Bioavailability: Moderate (intranasal)
- Storage: Solution: 2-8°C. Protected from light.
Dosing overview
- Typical dose: 250-750 mcg per spray dose
- Frequency: 2-3x daily
- Duration: 2-4 week courses
- Route: Intranasal spray
Protocol notes
- Delivered intranasally, split across 2-3 doses through the day.
- Run in 2-4 week courses; commonly stacked with Semax for a calm-but-focused nootropic combo.
Reported benefits
- Anxiolytic without sedation
- Improved memory/learning
- Cognitive flexibility
- Immune modulation
- BDNF upregulation
- No addiction
Possible side effects
- Nasal irritation
- Mild fatigue (initial)
- Headache (rare)
Research
- Selank anxiolytic effects vs benzodiazepines (2021): Equivalent anxiolysis to diazepam in GAD without cognitive impairment or dependence over 8 weeks.
- BDNF modulation by selank (2020): Increased hippocampal BDNF by 60% and improved spatial memory by 35% in aged models.
Compare Selank
Community discussions about Selank
- Anyone switched from Selank to NA-Selank for longer effects? - 0 comments
- Thoughts on na semax and bdnf levels - 4 comments
- My experience trying a Semax and Selank combo for study stress - 4 comments
- My experience with Dihexa oral and the overstimulation issue? - 4 comments
- Trying Adamax nasal spray for focus – my two‑week log - 7 comments
- Ask the community about Selank
Research and educational reference only. Not medical advice.