GHRP-2 vs Ibutamoren (MK-677) Oral
A side-by-side research comparison of GHRP-2 and Ibutamoren (MK-677) Oral across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GHRP-2 | Ibutamoren (MK-677) Oral |
|---|---|---|
| Full name | Growth Hormone Releasing Peptide-2 (Pralmorelin) | Ibutamoren Mesylate (MK-677) |
| Category | Growth Hormone | Growth Hormone |
| Status | Research compound | Research compound |
| Mechanism | Potent GHSR-1a agonist stimulating GH release and appetite. Also mildly stimulates ACTH/cortisol release. | Mimics ghrelin at the GHS-R1a receptor in the pituitary and hypothalamus, stimulating sustained GH release without suppressing natural pulsatility. Also increases appetite via ghrelin pathway activation. |
| Molecular weight | 818 Da | 528.66 Da |
| Half-life | 1-2 hours | ~24 hours |
| Bioavailability | High (SubQ) | ~60% oral |
| Typical dose | 100-300 mcg | 10-25 mg |
| Frequency | 2-3x daily | Once daily (evening) |
| Route | Subcutaneous | Oral capsule or liquid |
GHRP-2 reported benefits
- Strongest GH release among GHRPs
- Appetite stimulation
- Recovery improvement
- Enhanced sleep
- Muscle preservation
Ibutamoren (MK-677) Oral reported benefits
- Elevated IGF-1 levels
- Improved sleep quality
- Enhanced recovery
- Increased lean mass
- Better skin/hair
- Convenient oral dosing
Related comparisons
Research and educational reference only. Not medical advice.