Ibutamoren (MK-677) Oral (Ibutamoren Mesylate (MK-677))
An oral growth hormone secretagogue commonly prescribed by telemedicine clinics as a convenient alternative to injectable GH peptides. Provides sustained GH/IGF-1 elevation with once-daily oral dosing.
How it works
Mimics ghrelin at the GHS-R1a receptor in the pituitary and hypothalamus, stimulating sustained GH release without suppressing natural pulsatility. Also increases appetite via ghrelin pathway activation.
Key facts
- Molecular weight: 528.66 Da
- Half-life: ~24 hours
- Bioavailability: ~60% oral
- Storage: Room temperature.
Dosing overview
- Typical dose: 10-25 mg
- Frequency: Once daily (evening)
- Duration: 12-24 weeks or longer
- Route: Oral capsule or liquid
Protocol notes
- Most run 12.5-25 mg once daily; 25 mg is the common ceiling for body-composition goals.
- Evening dosing is typical to support sleep and align with the overnight GH pulse.
- Expect noticeable hunger and some water retention, especially in the first weeks.
Reported benefits
- Elevated IGF-1 levels
- Improved sleep quality
- Enhanced recovery
- Increased lean mass
- Better skin/hair
- Convenient oral dosing
Possible side effects
- Increased hunger
- Water retention
- Numbness/tingling
- Elevated blood sugar
- Lethargy
- Vivid dreams
Research
- MK-677 long-term GH elevation safety (2021): Maintained elevated IGF-1 levels for 12+ months without tachyphylaxis or significant adverse events in healthy adults.
Compare Ibutamoren (MK-677) Oral
Research and educational reference only. Not medical advice.