GHRP-2 (Growth Hormone Releasing Peptide-2 (Pralmorelin))
A synthetic hexapeptide and one of the most potent GHRPs. Produces strong GH release but also modestly increases cortisol and prolactin.
How it works
Potent GHSR-1a agonist stimulating GH release and appetite. Also mildly stimulates ACTH/cortisol release.
Key facts
- Molecular weight: 818 Da
- Half-life: 1-2 hours
- Bioavailability: High (SubQ)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 21 days.
Dosing overview
- Typical dose: 100-300 mcg
- Frequency: 2-3x daily
- Duration: 8-12 weeks
- Route: Subcutaneous
Reported benefits
- Strongest GH release among GHRPs
- Appetite stimulation
- Recovery improvement
- Enhanced sleep
- Muscle preservation
Possible side effects
- Increased appetite (significant)
- Cortisol elevation (mild)
- Prolactin increase
- Water retention
Research
- Comparative GH-releasing efficacy of GHRP-2 vs GHRP-6 (2018): GHRP-2 produced 40% higher peak GH than GHRP-6 with slightly less appetite stimulation.
- GHRP-2 combined with GHRH for optimal stimulation (2019): Combination produced synergistic GH release 3-5x greater than either alone.
Compare GHRP-2
Community discussions about GHRP-2
- GHRP-2 vs ipamorelin, is the extra GH pulse worth the cortisol and prolactin hit? - 6 comments
- Noticed water retention and appetite spike on GHRP-2 – anyone track labs? - 8 comments
- Recent GHRP-2 trial on sleep and recovery – what I think - 7 comments
- GH pulse timing with GHRP-2 after training, anyone dialled this in? - 4 comments
- thoughts on switching from ghrp-2 to sermorelin for better sleep - 4 comments
- Ask the community about GHRP-2
Research and educational reference only. Not medical advice.