ResearchSafe

GHRP-2 (Growth Hormone Releasing Peptide-2 (Pralmorelin))

Category: Growth Hormone. Status: Research compound.

A synthetic hexapeptide and one of the most potent GHRPs. Produces strong GH release but also modestly increases cortisol and prolactin.

How it works

Potent GHSR-1a agonist stimulating GH release and appetite. Also mildly stimulates ACTH/cortisol release.

Key facts

  • Molecular weight: 818 Da
  • Half-life: 1-2 hours
  • Bioavailability: High (SubQ)
  • Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 21 days.

Dosing overview

  • Typical dose: 100-300 mcg
  • Frequency: 2-3x daily
  • Duration: 8-12 weeks
  • Route: Subcutaneous

Reported benefits

  • Strongest GH release among GHRPs
  • Appetite stimulation
  • Recovery improvement
  • Enhanced sleep
  • Muscle preservation

Possible side effects

  • Increased appetite (significant)
  • Cortisol elevation (mild)
  • Prolactin increase
  • Water retention

Research

  • Comparative GH-releasing efficacy of GHRP-2 vs GHRP-6 (2018): GHRP-2 produced 40% higher peak GH than GHRP-6 with slightly less appetite stimulation.
  • GHRP-2 combined with GHRH for optimal stimulation (2019): Combination produced synergistic GH release 3-5x greater than either alone.

Community reviews of GHRP-2

Rated 4.8 out of 5 from 9 community reviews by ResearchSafe members.

  • peak_levels_paula rated it 5/5 - Body comp changes subtle but real: About 6 weeks into my GHRP-2 protocol and the compound is doing what it is supposed to. Sleep is deeper, skin quality is better, fat around the midsection is slowly reducing, and my recovery from training is improved. The key insight I have learned is patience. This is not an overnight transformation. It is a slow, steady optimization that compounds over weeks and months. People who quit after 2 weeks are not giving it enough time. Only downsides: some mild joint stiffness early on (actually a sign it is working) and the fasted dosing schedule is sometimes inconvenient. Worth it for the over
  • protocol_pete rated it 5/5 - Sleep quality improvement was the first thing I noticed: Running GHRP-2 for 2 months now, primarily for recovery and body composition. The first benefit I noticed was dramatically better sleep, deeper and more restorative, within the first week. Body composition changes came slower but are real. Leaner midsection, slightly fuller muscles, and my recovery between training sessions is noticeably improved. Not dramatic bodybuilder gains, more like everything works a bit better. Side effects have been minimal. Some water retention in the first 2 weeks that settled down, and occasional numbness in my fingers in the morning that goes away within an hour
  • dose_diary_alex rated it 5/5 - Gradual but consistent results: About 1 month into my GHRP-2 protocol and the compound is doing what it is supposed to. Sleep is deeper, skin quality is better, fat around the midsection is slowly reducing, and my recovery from training is improved. The key insight I have learned is patience. This is not an overnight transformation. It is a slow, steady optimization that compounds over weeks and months. People who quit after 2 weeks are not giving it enough time. Only downsides: some mild joint stiffness early on (actually a sign it is working) and the fasted dosing schedule is sometimes inconvenient. Worth it for the over
  • codes_nomad rated it 4/5 - Night shifts, stubborn appetite, and a better cut: I tried GHRP-2 during a 12-week cut because ICU nights had my hunger and recovery all over the place, and I was tired of dragging through lifts after a shift on the West Coast. For me, the big thing was appetite came up fast, which made it easier to eat enough protein and stay on track, and I dropped about 19 lbs over that stretch. Sleep seemed a bit deeper too, but the hunger spike was the one caveat, tbh. Rating it 4 out of 5.
  • researcher_rational rated it 5/5 - steady appetite, deeper sleep, better recovery: i ran ghrp-2 for about 4 months while juggling grad school, east coast winter, and a pretty stubborn training schedule in my 50s. for me, it was the strongest ghrelin-style peptide i tried, and the appetite bump was obvious fast. i also felt like i was recovering a bit better between lifts, and my sleep got heavier in a way that seemed useful, even if some of that could just be my own read on it. i did not see anything wild, but the overall effect was clear enough that i kept using it. 5 out of 5 from me.
  • titrate_tina rated it 5/5 - Better recovery and deeper sleep at 6 months: GHRP-2 has been a solid addition to my protocol. The GH release translates to better sleep, improved recovery, and a gradual improvement in body composition that I did not get from training alone. I track my sleep with a wearable and my deep sleep percentage went from 12% to about 18-20% within the first two weeks. That alone is worth it for recovery. The body comp changes are more subtle but visible in progress photos over 2-3 months. No significant side effects at the doses I am running. Occasionally wake up with slightly puffy hands but it resolves within an hour. Recommend starting conse

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Community discussions about GHRP-2

Research and educational reference only. Not medical advice.